Cysteamine Supplementation of <i>In vitro</i> Maturation Media: A Review

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<jats:title>Contents</jats:title><jats:p>Under <jats:italic>in vitro</jats:italic> culture conditions, oxidative modifications of cell components via increased reactive oxygen species (ROS) represent a major culture induced stress. Anti‐oxidant systems such as glutathione (GSH) can attenuate the deleterious effects of oxidative stress by scavenging ROS. It has been suggested that GSH content in oocytes may serve as a reservoir protecting the zygote and the early embryos from oxidative damage before genomic activation and <jats:italic>de novo</jats:italic> GSH synthesis occur. Addition of low molecular weight compounds to culture media, such as cysteamine, can increase GSH levels by increasing cysteine uptake. Quite naturally, effects of supplementation of <jats:italic>in vitro</jats:italic> maturation (IVM) media with low molecular weight thiols have been studied in various species. This article reviews the use of cysteamine supplementation for IVM, its effects on maturation rates and further embryo development.</jats:p>

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