Inner ear autoantibodies in patients with rapidly progressive sensorineural hearing loss

DOI Web Site Web Site 被引用文献24件

書誌事項

公開日
1990-05
権利情報
  • http://onlinelibrary.wiley.com/termsAndConditions#vor
DOI
  • 10.1288/00005537-199005000-00015
公開者
Wiley

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説明

<jats:title>Abstract</jats:title><jats:p>Recognition of immune‐mediated sensorineural deafness that responds to immunosuppressive therapy has led to a search for a diagnostic assay to identify inner ear autoantibodies. Without a confirmed diagnosis of autoimmune disease, many patients have undergone inappropriate immunosuppressive treatment or developed irreversible inner ear damage.</jats:p><jats:p>Serum from patients with progressive sensorineural hearing loss (N=54), ulcerative colitis (N=5), normal controls (N=14), and animals with experimental autoimmune sensorineural hearing loss (EASNHL) were analyzed by Western blot against fresh bovine inner ear antigen preparations. The hearing loss group (19 [35%]) showed a single‐or double‐band migrating at 68,000 molecular weight (MW), differing from the normal group (1 of 14 [7%]) which showed a similar band (<jats:italic>P</jats:italic> = .031).</jats:p><jats:p>Upon analysis by two‐dimensional gel electrophoresis both the EASNHL guinea pigs and a patient reacted against identical components of inner ear antigen. These results suggest an autoimmune basis for disease in patients reacting against the 68,000 MW antigen.</jats:p>

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