Discrimination between Sjögren's and Non-Sjögren's Sicca Syndrome by Sialoscintigraphy and Antibodies against α-Fodrin and Ro/La Autoantigens

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  • K-S Chen
    Department of Allergy, Immunology and Rheumatology, Tungs' Taichung MetroHarbor Hospital, Taichung, Taiwan
  • M-C Jiang
    Department of Medical Research, Tungs' Taichung MetroHarbor Hospital, Taichung, Taiwan
  • C-J Li
    Department of Medical Research, Tungs' Taichung MetroHarbor Hospital, Taichung, Taiwan
  • O-K Liu
    Department of Nuclear Medicine, Tungs' Taichung MetroHarbor Hospital, Taichung, Taiwan
  • C-SS Tsai
    Department of Medical Research, Tungs' Taichung MetroHarbor Hospital, Taichung, Taiwan

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<jats:p> Both Sjögren's syndrome (SS) and non-Sjögren's syndrome (NSS) can present with the sicca symptoms of dry eyes and a dry mouth but they are distinct pathological entities that require diagnostic discrimination. This study included 82 sicca syndrome patients and examined the ability of sialoscintigraphy and antibodies against the autoantigens α-fodrin, Ro and La to discriminate between SS and NSS. A total of 30.8% of SS patients compared with 58.8% of NSS patients were α-fodrin positive. The prevalence of Ro positivity was 69.4% for SS patients compared with 0% for NSS patients. The prevalence of La positivity was 52.4% for SS compared with 0% for NSS patients. Sialoscintigraphy showed that more NSS patients had grade III salivary gland impairment compared with SS patients (64.7% versus 19.4%). These data suggest that using sialoscintigraphy in combination with measuring the levels of serum α-fodrin, Ro and La might be useful for SS and NSS discrimination. </jats:p>

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