-
- Basil P. Hubbard
- Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
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- Ana P. Gomes
- Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
-
- Han Dai
- Sirtris, a GSK Company, Cambridge, MA 02139, USA.
-
- Jun Li
- Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
-
- April W. Case
- Sirtris, a GSK Company, Cambridge, MA 02139, USA.
-
- Thomas Considine
- Sirtris, a GSK Company, Cambridge, MA 02139, USA.
-
- Thomas V. Riera
- Sirtris, a GSK Company, Cambridge, MA 02139, USA.
-
- Jessica E. Lee
- ExSAR Corporation, Monmouth Junction, NJ 08852, USA.
-
- Sook Yen E
- ExSAR Corporation, Monmouth Junction, NJ 08852, USA.
-
- Dudley W. Lamming
- Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
-
- Bradley L. Pentelute
- Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
-
- Eli R. Schuman
- Sirtris, a GSK Company, Cambridge, MA 02139, USA.
-
- Linda A. Stevens
- NIH Cardiovascular and Pulmonary Branch/National Heart, Lung and Blood Institute, Bethesda, MD 20892, USA.
-
- Alvin J. Y. Ling
- Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
-
- Sean M. Armour
- Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
-
- Shaday Michan
- Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
-
- Huizhen Zhao
- GlaxoSmithKline, Collegeville, PA 19426, USA.
-
- Yong Jiang
- GlaxoSmithKline, Collegeville, PA 19426, USA.
-
- Sharon M. Sweitzer
- GlaxoSmithKline, Collegeville, PA 19426, USA.
-
- Charles A. Blum
- Sirtris, a GSK Company, Cambridge, MA 02139, USA.
-
- Jeremy S. Disch
- Sirtris, a GSK Company, Cambridge, MA 02139, USA.
-
- Pui Yee Ng
- Sirtris, a GSK Company, Cambridge, MA 02139, USA.
-
- Konrad T. Howitz
- BIOMOL Research Laboratories Inc., Plymouth Meeting, PA 19462, USA.
-
- Anabela P. Rolo
- Center for Neurosciences and Cell Biology, Department of Life Sciences, University of Coimbra, Coimbra 3004-517, Portugal.
-
- Yoshitomo Hamuro
- ExSAR Corporation, Monmouth Junction, NJ 08852, USA.
-
- Joel Moss
- NIH Cardiovascular and Pulmonary Branch/National Heart, Lung and Blood Institute, Bethesda, MD 20892, USA.
-
- Robert B. Perni
- Sirtris, a GSK Company, Cambridge, MA 02139, USA.
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- James L. Ellis
- Sirtris, a GSK Company, Cambridge, MA 02139, USA.
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- George P. Vlasuk
- Sirtris, a GSK Company, Cambridge, MA 02139, USA.
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- David A. Sinclair
- Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
書誌事項
- 公開日
- 2013-03-08
- DOI
-
- 10.1126/science.1231097
- 公開者
- American Association for the Advancement of Science (AAAS)
この論文をさがす
説明
<jats:title>It's a SIRT</jats:title> <jats:p> Intense attention has focused on the SIRT1 deacetylase as a possible target for anti-aging drugs. But unexpected complications in assays of SIRT1 activity have made it unclear whether compounds thought to be sirtuin-activating compounds (STACs) are really direct regulators of the enzyme. Further exploration of these effects by <jats:bold> Hubbard <jats:italic>et al.</jats:italic> </jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6124" page="1216" related-article-type="in-this-issue" vol="339" xlink:href="10.1126/science.1231097">1216</jats:related-article> ; see the Perspective by <jats:bold>Yuan and Marmorstein</jats:bold> ) revealed that interaction of SIRT1 with certain substrates allows activation of SIRT1 by STACs and identified critical amino acids in SIRT1 required for these effects. Mouse myoblasts reconstituted with SIRT1 mutated at this amino acid lost their responsiveness to STACs. </jats:p>
収録刊行物
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- Science
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Science 339 (6124), 1216-1219, 2013-03-08
American Association for the Advancement of Science (AAAS)