Expanding expression of the 5-lipoxygenase pathway within the arterial wall during human atherogenesis
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- Rainer Spanbroek
- Institute for Vascular Medicine, Friedrich-Schiller-University of Jena, Nordhäuserstrasse 78, 99089 Erfurt, Germany; Department of Cardio-Thoracic and Vascular Surgery, Friedrich-Schiller-University of Jena, Bachstrasse 18, 07740 Jena, Germany; Department of Pathology, Louisiana State University Medical Center, New Orleans, LA 70112-1393; Institute for Atherosclerosis Research, Domagkstrasse 3, 48149 Münster, Germany; Department of Medicine, Division of Cardiology, University of Heidelberg Medical...
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- Rolf Gräbner
- Institute for Vascular Medicine, Friedrich-Schiller-University of Jena, Nordhäuserstrasse 78, 99089 Erfurt, Germany; Department of Cardio-Thoracic and Vascular Surgery, Friedrich-Schiller-University of Jena, Bachstrasse 18, 07740 Jena, Germany; Department of Pathology, Louisiana State University Medical Center, New Orleans, LA 70112-1393; Institute for Atherosclerosis Research, Domagkstrasse 3, 48149 Münster, Germany; Department of Medicine, Division of Cardiology, University of Heidelberg Medical...
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- Katharina Lötzer
- Institute for Vascular Medicine, Friedrich-Schiller-University of Jena, Nordhäuserstrasse 78, 99089 Erfurt, Germany; Department of Cardio-Thoracic and Vascular Surgery, Friedrich-Schiller-University of Jena, Bachstrasse 18, 07740 Jena, Germany; Department of Pathology, Louisiana State University Medical Center, New Orleans, LA 70112-1393; Institute for Atherosclerosis Research, Domagkstrasse 3, 48149 Münster, Germany; Department of Medicine, Division of Cardiology, University of Heidelberg Medical...
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- Markus Hildner
- Institute for Vascular Medicine, Friedrich-Schiller-University of Jena, Nordhäuserstrasse 78, 99089 Erfurt, Germany; Department of Cardio-Thoracic and Vascular Surgery, Friedrich-Schiller-University of Jena, Bachstrasse 18, 07740 Jena, Germany; Department of Pathology, Louisiana State University Medical Center, New Orleans, LA 70112-1393; Institute for Atherosclerosis Research, Domagkstrasse 3, 48149 Münster, Germany; Department of Medicine, Division of Cardiology, University of Heidelberg Medical...
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- Anja Urbach
- Institute for Vascular Medicine, Friedrich-Schiller-University of Jena, Nordhäuserstrasse 78, 99089 Erfurt, Germany; Department of Cardio-Thoracic and Vascular Surgery, Friedrich-Schiller-University of Jena, Bachstrasse 18, 07740 Jena, Germany; Department of Pathology, Louisiana State University Medical Center, New Orleans, LA 70112-1393; Institute for Atherosclerosis Research, Domagkstrasse 3, 48149 Münster, Germany; Department of Medicine, Division of Cardiology, University of Heidelberg Medical...
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- Katharina Rühling
- Institute for Vascular Medicine, Friedrich-Schiller-University of Jena, Nordhäuserstrasse 78, 99089 Erfurt, Germany; Department of Cardio-Thoracic and Vascular Surgery, Friedrich-Schiller-University of Jena, Bachstrasse 18, 07740 Jena, Germany; Department of Pathology, Louisiana State University Medical Center, New Orleans, LA 70112-1393; Institute for Atherosclerosis Research, Domagkstrasse 3, 48149 Münster, Germany; Department of Medicine, Division of Cardiology, University of Heidelberg Medical...
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- Michael P. W. Moos
- Institute for Vascular Medicine, Friedrich-Schiller-University of Jena, Nordhäuserstrasse 78, 99089 Erfurt, Germany; Department of Cardio-Thoracic and Vascular Surgery, Friedrich-Schiller-University of Jena, Bachstrasse 18, 07740 Jena, Germany; Department of Pathology, Louisiana State University Medical Center, New Orleans, LA 70112-1393; Institute for Atherosclerosis Research, Domagkstrasse 3, 48149 Münster, Germany; Department of Medicine, Division of Cardiology, University of Heidelberg Medical...
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- Brigitte Kaiser
- Institute for Vascular Medicine, Friedrich-Schiller-University of Jena, Nordhäuserstrasse 78, 99089 Erfurt, Germany; Department of Cardio-Thoracic and Vascular Surgery, Friedrich-Schiller-University of Jena, Bachstrasse 18, 07740 Jena, Germany; Department of Pathology, Louisiana State University Medical Center, New Orleans, LA 70112-1393; Institute for Atherosclerosis Research, Domagkstrasse 3, 48149 Münster, Germany; Department of Medicine, Division of Cardiology, University of Heidelberg Medical...
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- Tina U. Cohnert
- Institute for Vascular Medicine, Friedrich-Schiller-University of Jena, Nordhäuserstrasse 78, 99089 Erfurt, Germany; Department of Cardio-Thoracic and Vascular Surgery, Friedrich-Schiller-University of Jena, Bachstrasse 18, 07740 Jena, Germany; Department of Pathology, Louisiana State University Medical Center, New Orleans, LA 70112-1393; Institute for Atherosclerosis Research, Domagkstrasse 3, 48149 Münster, Germany; Department of Medicine, Division of Cardiology, University of Heidelberg Medical...
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- Thorsten Wahlers
- Institute for Vascular Medicine, Friedrich-Schiller-University of Jena, Nordhäuserstrasse 78, 99089 Erfurt, Germany; Department of Cardio-Thoracic and Vascular Surgery, Friedrich-Schiller-University of Jena, Bachstrasse 18, 07740 Jena, Germany; Department of Pathology, Louisiana State University Medical Center, New Orleans, LA 70112-1393; Institute for Atherosclerosis Research, Domagkstrasse 3, 48149 Münster, Germany; Department of Medicine, Division of Cardiology, University of Heidelberg Medical...
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- Arthur Zieske
- Institute for Vascular Medicine, Friedrich-Schiller-University of Jena, Nordhäuserstrasse 78, 99089 Erfurt, Germany; Department of Cardio-Thoracic and Vascular Surgery, Friedrich-Schiller-University of Jena, Bachstrasse 18, 07740 Jena, Germany; Department of Pathology, Louisiana State University Medical Center, New Orleans, LA 70112-1393; Institute for Atherosclerosis Research, Domagkstrasse 3, 48149 Münster, Germany; Department of Medicine, Division of Cardiology, University of Heidelberg Medical...
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- Gabriele Plenz
- Institute for Vascular Medicine, Friedrich-Schiller-University of Jena, Nordhäuserstrasse 78, 99089 Erfurt, Germany; Department of Cardio-Thoracic and Vascular Surgery, Friedrich-Schiller-University of Jena, Bachstrasse 18, 07740 Jena, Germany; Department of Pathology, Louisiana State University Medical Center, New Orleans, LA 70112-1393; Institute for Atherosclerosis Research, Domagkstrasse 3, 48149 Münster, Germany; Department of Medicine, Division of Cardiology, University of Heidelberg Medical...
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- Horst Robenek
- Institute for Vascular Medicine, Friedrich-Schiller-University of Jena, Nordhäuserstrasse 78, 99089 Erfurt, Germany; Department of Cardio-Thoracic and Vascular Surgery, Friedrich-Schiller-University of Jena, Bachstrasse 18, 07740 Jena, Germany; Department of Pathology, Louisiana State University Medical Center, New Orleans, LA 70112-1393; Institute for Atherosclerosis Research, Domagkstrasse 3, 48149 Münster, Germany; Department of Medicine, Division of Cardiology, University of Heidelberg Medical...
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- Peter Salbach
- Institute for Vascular Medicine, Friedrich-Schiller-University of Jena, Nordhäuserstrasse 78, 99089 Erfurt, Germany; Department of Cardio-Thoracic and Vascular Surgery, Friedrich-Schiller-University of Jena, Bachstrasse 18, 07740 Jena, Germany; Department of Pathology, Louisiana State University Medical Center, New Orleans, LA 70112-1393; Institute for Atherosclerosis Research, Domagkstrasse 3, 48149 Münster, Germany; Department of Medicine, Division of Cardiology, University of Heidelberg Medical...
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- Hartmut Kühn
- Institute for Vascular Medicine, Friedrich-Schiller-University of Jena, Nordhäuserstrasse 78, 99089 Erfurt, Germany; Department of Cardio-Thoracic and Vascular Surgery, Friedrich-Schiller-University of Jena, Bachstrasse 18, 07740 Jena, Germany; Department of Pathology, Louisiana State University Medical Center, New Orleans, LA 70112-1393; Institute for Atherosclerosis Research, Domagkstrasse 3, 48149 Münster, Germany; Department of Medicine, Division of Cardiology, University of Heidelberg Medical...
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- Olof Rådmark
- Institute for Vascular Medicine, Friedrich-Schiller-University of Jena, Nordhäuserstrasse 78, 99089 Erfurt, Germany; Department of Cardio-Thoracic and Vascular Surgery, Friedrich-Schiller-University of Jena, Bachstrasse 18, 07740 Jena, Germany; Department of Pathology, Louisiana State University Medical Center, New Orleans, LA 70112-1393; Institute for Atherosclerosis Research, Domagkstrasse 3, 48149 Münster, Germany; Department of Medicine, Division of Cardiology, University of Heidelberg Medical...
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- Bengt Samuelsson
- Institute for Vascular Medicine, Friedrich-Schiller-University of Jena, Nordhäuserstrasse 78, 99089 Erfurt, Germany; Department of Cardio-Thoracic and Vascular Surgery, Friedrich-Schiller-University of Jena, Bachstrasse 18, 07740 Jena, Germany; Department of Pathology, Louisiana State University Medical Center, New Orleans, LA 70112-1393; Institute for Atherosclerosis Research, Domagkstrasse 3, 48149 Münster, Germany; Department of Medicine, Division of Cardiology, University of Heidelberg Medical...
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- Andreas J. R. Habenicht
- Institute for Vascular Medicine, Friedrich-Schiller-University of Jena, Nordhäuserstrasse 78, 99089 Erfurt, Germany; Department of Cardio-Thoracic and Vascular Surgery, Friedrich-Schiller-University of Jena, Bachstrasse 18, 07740 Jena, Germany; Department of Pathology, Louisiana State University Medical Center, New Orleans, LA 70112-1393; Institute for Atherosclerosis Research, Domagkstrasse 3, 48149 Münster, Germany; Department of Medicine, Division of Cardiology, University of Heidelberg Medical...
説明
<jats:p>Oxidation products of low-density lipoproteins have been suggested to promote inflammation during atherogenesis, and reticulocyte-type 15-lipoxygenase has been implicated to mediate this oxidation. In addition, the 5-lipoxygenase cascade leads to formation of leukotrienes, which exhibit strong proinflammatory activities in cardiovascular tissues. Here, we studied both lipoxygenase pathways in human atherosclerosis. The 5-lipoxygenase pathway was abundantly expressed in arterial walls of patients afflicted with various lesion stages of atherosclerosis of the aorta and of coronary and carotid arteries. 5-lipoxygenase localized to macrophages, dendritic cells, foam cells, mast cells, and neutrophilic granulocytes, and the number of 5-lipoxygenase expressing cells markedly increased in advanced lesions. By contrast, reticulocyte-type 15-lipoxygenase was expressed at levels that were several orders of magnitude lower than 5-lipoxygenase in both normal and diseased arteries, and its expression could not be related to lesion pathology. Our data support a model of atherogenesis in which 5-lipoxygenase cascade-dependent inflammatory circuits consisting of several leukocyte lineages and arterial wall cells evolve within the blood vessel wall during critical stages of lesion development. They raise the possibility that antileukotriene drugs may be an effective treatment regimen in late-stage disease.</jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 100 (3), 1238-1243, 2003-01-27
Proceedings of the National Academy of Sciences