Proteins of the malaria parasite sexual stages: expression, function and potential for transmission blocking strategies
書誌事項
- 公開日
- 2007-08-23
- 権利情報
-
- https://www.cambridge.org/core/terms
- DOI
-
- 10.1017/s0031182007003381
- 公開者
- Cambridge University Press (CUP)
この論文をさがす
説明
<jats:title>SUMMARY</jats:title><jats:p>The sexual phase of the malaria pathogen,<jats:italic>Plasmodium falciparum</jats:italic>, culminates in fertilization within the midgut of the mosquito and represents a crucial step in the completion of the parasite's life-cycle and transmission of the disease. Two decades ago, the first sexual stage-specific surface proteins were identified, among them<jats:italic>Pf</jats:italic>s230,<jats:italic>Pf</jats:italic>s48/45, and<jats:italic>Pf</jats:italic>s25, which were of scientific interest as candidates for the development of transmission blocking vaccines. A decade later, gene information gained from the sequencing of the<jats:italic>P. falciparum</jats:italic>genome led to the identification of numerous additional sexual-stage proteins with antigenic properties and novel enzymes that putatively possess regulatory functions during sexual-stage development. This review aims to summarize the sexual-stage proteins identified to date, to compare their stage specificities and expression patterns and to highlight novel regulative mechanisms of sexual differentiation. The prospective candidacy of select sexual-stage proteins as targets for transmission blocking strategies will be discussed.</jats:p>
収録刊行物
-
- Parasitology
-
Parasitology 134 (14), 1911-1929, 2007-08-23
Cambridge University Press (CUP)