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- Patrícia Alexandra Madureira
- editor
書誌事項
- 公開日
- 2015-11-30
- 権利情報
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- http://creativecommons.org/licenses/by/4.0/
- DOI
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- 10.1155/2016/1958174
- 公開者
- Wiley
この論文をさがす
説明
<jats:p>The transcription factor, nuclear factor erythroid 2 p45‐related factor 2 (Nrf2), acts as a sensor of oxidative or electrophilic stresses and plays a pivotal role in redox homeostasis. Oxidative or electrophilic agents cause a conformational change in the Nrf2 inhibitory protein Keap1 inducing the nuclear translocation of the transcription factor which, through its binding to the antioxidant/electrophilic response element (ARE/EpRE), regulates the expression of antioxidant and detoxifying genes such as heme oxygenase 1 (HO‐1). Nrf2 and HO‐1 are frequently upregulated in different types of tumours and correlate with tumour progression, aggressiveness, resistance to therapy, and poor prognosis. This review focuses on the Nrf2/HO‐1 stress response mechanism as a promising target for anticancer treatment which is able to overcome resistance to therapies.</jats:p>
収録刊行物
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- Oxidative Medicine and Cellular Longevity
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Oxidative Medicine and Cellular Longevity 2016 (1), 1958174-, 2015-11-30
Wiley