A transcriptional signature of hub connectivity in the mouse connectome

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  • Ben D. Fulcher
    Brain and Mental Health Laboratory, Monash Institute of Cognitive and Clinical Neurosciences, Monash University, Clayton, 3168 VIC, Australia
  • Alex Fornito
    Brain and Mental Health Laboratory, Monash Institute of Cognitive and Clinical Neurosciences, Monash University, Clayton, 3168 VIC, Australia

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<jats:title>Significance</jats:title> <jats:p>Some brain regions are highly connected with other areas, designating them as network hubs. These hubs are also heavily interconnected with each other, forming a dense core that integrates information across different neural systems. Here, we show that the functionally important projections linking hub areas of the mouse brain have a distinct genetic signature that is characterized by the tightly coupled expression of genes regulating the synthesis and metabolism of ATP, the primary energy source for neural activity. Our findings establish a direct link between molecular function and the large-scale organization of neuronal connectivity and suggest that coordinated gene expression between hub areas is closely related to the metabolic demands of these highly active and functionally important regions.</jats:p>

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