Characterization of an Avian Influenza A (H5N1) Virus Isolated from a Child with a Fatal Respiratory Illness

DOI Web Site 69 Citations
  • Kanta Subbarao
    K. Subbarao, A. Klimov, J. Katz, H. Regnery, H. Hall, C. Bender, J. Huang, M. Hemphill, T. Rowe, M. Shaw, X. Xu, K. Fukuda, N. Cox, Influenza Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
  • Alexander Klimov
    K. Subbarao, A. Klimov, J. Katz, H. Regnery, H. Hall, C. Bender, J. Huang, M. Hemphill, T. Rowe, M. Shaw, X. Xu, K. Fukuda, N. Cox, Influenza Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
  • Jacqueline Katz
    K. Subbarao, A. Klimov, J. Katz, H. Regnery, H. Hall, C. Bender, J. Huang, M. Hemphill, T. Rowe, M. Shaw, X. Xu, K. Fukuda, N. Cox, Influenza Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
  • Helen Regnery
    K. Subbarao, A. Klimov, J. Katz, H. Regnery, H. Hall, C. Bender, J. Huang, M. Hemphill, T. Rowe, M. Shaw, X. Xu, K. Fukuda, N. Cox, Influenza Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
  • Wilina Lim
    K. Subbarao, A. Klimov, J. Katz, H. Regnery, H. Hall, C. Bender, J. Huang, M. Hemphill, T. Rowe, M. Shaw, X. Xu, K. Fukuda, N. Cox, Influenza Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
  • Henrietta Hall
    K. Subbarao, A. Klimov, J. Katz, H. Regnery, H. Hall, C. Bender, J. Huang, M. Hemphill, T. Rowe, M. Shaw, X. Xu, K. Fukuda, N. Cox, Influenza Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
  • Michael Perdue
    K. Subbarao, A. Klimov, J. Katz, H. Regnery, H. Hall, C. Bender, J. Huang, M. Hemphill, T. Rowe, M. Shaw, X. Xu, K. Fukuda, N. Cox, Influenza Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
  • David Swayne
    K. Subbarao, A. Klimov, J. Katz, H. Regnery, H. Hall, C. Bender, J. Huang, M. Hemphill, T. Rowe, M. Shaw, X. Xu, K. Fukuda, N. Cox, Influenza Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
  • Catherine Bender
    K. Subbarao, A. Klimov, J. Katz, H. Regnery, H. Hall, C. Bender, J. Huang, M. Hemphill, T. Rowe, M. Shaw, X. Xu, K. Fukuda, N. Cox, Influenza Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
  • Jing Huang
    K. Subbarao, A. Klimov, J. Katz, H. Regnery, H. Hall, C. Bender, J. Huang, M. Hemphill, T. Rowe, M. Shaw, X. Xu, K. Fukuda, N. Cox, Influenza Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
  • Mark Hemphill
    K. Subbarao, A. Klimov, J. Katz, H. Regnery, H. Hall, C. Bender, J. Huang, M. Hemphill, T. Rowe, M. Shaw, X. Xu, K. Fukuda, N. Cox, Influenza Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
  • Thomas Rowe
    K. Subbarao, A. Klimov, J. Katz, H. Regnery, H. Hall, C. Bender, J. Huang, M. Hemphill, T. Rowe, M. Shaw, X. Xu, K. Fukuda, N. Cox, Influenza Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
  • Michael Shaw
    K. Subbarao, A. Klimov, J. Katz, H. Regnery, H. Hall, C. Bender, J. Huang, M. Hemphill, T. Rowe, M. Shaw, X. Xu, K. Fukuda, N. Cox, Influenza Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
  • Xiyan Xu
    K. Subbarao, A. Klimov, J. Katz, H. Regnery, H. Hall, C. Bender, J. Huang, M. Hemphill, T. Rowe, M. Shaw, X. Xu, K. Fukuda, N. Cox, Influenza Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
  • Keiji Fukuda
    K. Subbarao, A. Klimov, J. Katz, H. Regnery, H. Hall, C. Bender, J. Huang, M. Hemphill, T. Rowe, M. Shaw, X. Xu, K. Fukuda, N. Cox, Influenza Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
  • Nancy Cox
    K. Subbarao, A. Klimov, J. Katz, H. Regnery, H. Hall, C. Bender, J. Huang, M. Hemphill, T. Rowe, M. Shaw, X. Xu, K. Fukuda, N. Cox, Influenza Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.

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<jats:p>An avian H5N1 influenza A virus (A/Hong Kong/156/97) was isolated from a tracheal aspirate obtained from a 3-year-old child in Hong Kong with a fatal illness consistent with influenza. Serologic analysis indicated the presence of an H5 hemagglutinin. All eight RNA segments were derived from an avian influenza A virus. The hemagglutinin contained multiple basic amino acids adjacent to the cleavage site, a feature characteristic of highly pathogenic avian influenza A viruses. The virus caused 87.5 to 100 percent mortality in experimentally inoculated White Plymouth Rock and White Leghorn chickens. These results may have implications for global influenza surveillance and planning for pandemic influenza.</jats:p>

Journal

  • Science

    Science 279 (5349), 393-396, 1998-01-16

    American Association for the Advancement of Science (AAAS)

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