Biosynthetic investigation of phomopsins reveals a widespread pathway for ribosomal natural products in Ascomycetes

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  • Wei Ding
    Department of Chemistry, Fudan University, Shanghai 200433, China;
  • Wan-Qiu Liu
    Department of Chemistry, Fudan University, Shanghai 200433, China;
  • Youli Jia
    Department of Chemistry, Fudan University, Shanghai 200433, China;
  • Yongzhen Li
    Department of Chemistry, Fudan University, Shanghai 200433, China;
  • Wilfred A. van der Donk
    Department of Chemistry, University of Illinois at Urbana–Champaign, Urbana, IL 61801;
  • Qi Zhang
    Department of Chemistry, Fudan University, Shanghai 200433, China;

Abstract

<jats:title>Significance</jats:title> <jats:p>Ascomycetes are a prolific source of natural products that are of great significance for human health, yet production of ribosomally synthesized and posttranslationally modified peptides (RiPPs), a ubiquitous class of natural products, have rarely been reported in this fungal phylum. Here we show that phomopsins, a family of antimitotic mycotoxins, have a ribosomal origin and demonstrate the widespread presence of a fungal RiPP pathway for cyclic peptides that we term dikaritins. The framework described herein provides a foundation for mining for additional dikaritin members and investigating the biological activities and biosynthetic chemistry of this family of fungal natural products.</jats:p>

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