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- Dennis Wolf
- From the Department of Cardiology and Angiology I, University Heart Center Freiburg, Germany (D.W.)
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- Klaus Ley
- Division of Inflammation Biology, La Jolla Institute for Immunology, CA (K.L.)
説明
<jats:p>There is now overwhelming experimental and clinical evidence that atherosclerosis is a chronic inflammatory disease. Lessons from genome-wide association studies, advanced in vivo imaging techniques, transgenic lineage tracing mice, and clinical interventional studies have shown that both innate and adaptive immune mechanisms can accelerate or curb atherosclerosis. Here, we summarize and discuss the pathogenesis of atherosclerosis with a focus on adaptive immunity. We discuss some limitations of animal models and the need for models that are tailored to better translate to human atherosclerosis and ultimately progress in prevention and treatment.</jats:p>
収録刊行物
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- Circulation Research
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Circulation Research 124 (2), 315-327, 2019-01-18
Ovid Technologies (Wolters Kluwer Health)
