Vascular Tissue Reaction to Acute Malapposition in Human Coronary Arteries

DOI Web Site 被引用文献9件
  • Juan Luis Gutiérrez-Chico
    From the Erasmus Medical Centre–Thoraxcentre, Rotterdam, The Netherlands (J.L.G.-C., J.W., E.R., P.W.S., R.J.v.G.); Institute for Social and Preventive Medicine, University of Bern, Bern, Switzerland (E.N., P.J.); CTU Bern, Bern University Hospital, Bern, Switzerland (E.N., P.J.); Academisch Medisch Centrum, Amsterdam, The Netherlands (K.T.K.); Catharina Ziekenhuis, Eindhoven, The Netherlands (J.J.K.); Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Trust, London, United...
  • Joanna Wykrzykowska
    From the Erasmus Medical Centre–Thoraxcentre, Rotterdam, The Netherlands (J.L.G.-C., J.W., E.R., P.W.S., R.J.v.G.); Institute for Social and Preventive Medicine, University of Bern, Bern, Switzerland (E.N., P.J.); CTU Bern, Bern University Hospital, Bern, Switzerland (E.N., P.J.); Academisch Medisch Centrum, Amsterdam, The Netherlands (K.T.K.); Catharina Ziekenhuis, Eindhoven, The Netherlands (J.J.K.); Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Trust, London, United...
  • Eveline Nüesch
    From the Erasmus Medical Centre–Thoraxcentre, Rotterdam, The Netherlands (J.L.G.-C., J.W., E.R., P.W.S., R.J.v.G.); Institute for Social and Preventive Medicine, University of Bern, Bern, Switzerland (E.N., P.J.); CTU Bern, Bern University Hospital, Bern, Switzerland (E.N., P.J.); Academisch Medisch Centrum, Amsterdam, The Netherlands (K.T.K.); Catharina Ziekenhuis, Eindhoven, The Netherlands (J.J.K.); Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Trust, London, United...
  • Robert Jan van Geuns
    From the Erasmus Medical Centre–Thoraxcentre, Rotterdam, The Netherlands (J.L.G.-C., J.W., E.R., P.W.S., R.J.v.G.); Institute for Social and Preventive Medicine, University of Bern, Bern, Switzerland (E.N., P.J.); CTU Bern, Bern University Hospital, Bern, Switzerland (E.N., P.J.); Academisch Medisch Centrum, Amsterdam, The Netherlands (K.T.K.); Catharina Ziekenhuis, Eindhoven, The Netherlands (J.J.K.); Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Trust, London, United...
  • Karel T. Koch
    From the Erasmus Medical Centre–Thoraxcentre, Rotterdam, The Netherlands (J.L.G.-C., J.W., E.R., P.W.S., R.J.v.G.); Institute for Social and Preventive Medicine, University of Bern, Bern, Switzerland (E.N., P.J.); CTU Bern, Bern University Hospital, Bern, Switzerland (E.N., P.J.); Academisch Medisch Centrum, Amsterdam, The Netherlands (K.T.K.); Catharina Ziekenhuis, Eindhoven, The Netherlands (J.J.K.); Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Trust, London, United...
  • Jacques J. Koolen
    From the Erasmus Medical Centre–Thoraxcentre, Rotterdam, The Netherlands (J.L.G.-C., J.W., E.R., P.W.S., R.J.v.G.); Institute for Social and Preventive Medicine, University of Bern, Bern, Switzerland (E.N., P.J.); CTU Bern, Bern University Hospital, Bern, Switzerland (E.N., P.J.); Academisch Medisch Centrum, Amsterdam, The Netherlands (K.T.K.); Catharina Ziekenhuis, Eindhoven, The Netherlands (J.J.K.); Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Trust, London, United...
  • Carlo di Mario
    From the Erasmus Medical Centre–Thoraxcentre, Rotterdam, The Netherlands (J.L.G.-C., J.W., E.R., P.W.S., R.J.v.G.); Institute for Social and Preventive Medicine, University of Bern, Bern, Switzerland (E.N., P.J.); CTU Bern, Bern University Hospital, Bern, Switzerland (E.N., P.J.); Academisch Medisch Centrum, Amsterdam, The Netherlands (K.T.K.); Catharina Ziekenhuis, Eindhoven, The Netherlands (J.J.K.); Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Trust, London, United...
  • Stephan Windecker
    From the Erasmus Medical Centre–Thoraxcentre, Rotterdam, The Netherlands (J.L.G.-C., J.W., E.R., P.W.S., R.J.v.G.); Institute for Social and Preventive Medicine, University of Bern, Bern, Switzerland (E.N., P.J.); CTU Bern, Bern University Hospital, Bern, Switzerland (E.N., P.J.); Academisch Medisch Centrum, Amsterdam, The Netherlands (K.T.K.); Catharina Ziekenhuis, Eindhoven, The Netherlands (J.J.K.); Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Trust, London, United...
  • Gerrit-Anne van Es
    From the Erasmus Medical Centre–Thoraxcentre, Rotterdam, The Netherlands (J.L.G.-C., J.W., E.R., P.W.S., R.J.v.G.); Institute for Social and Preventive Medicine, University of Bern, Bern, Switzerland (E.N., P.J.); CTU Bern, Bern University Hospital, Bern, Switzerland (E.N., P.J.); Academisch Medisch Centrum, Amsterdam, The Netherlands (K.T.K.); Catharina Ziekenhuis, Eindhoven, The Netherlands (J.J.K.); Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Trust, London, United...
  • Pierre Gobbens
    From the Erasmus Medical Centre–Thoraxcentre, Rotterdam, The Netherlands (J.L.G.-C., J.W., E.R., P.W.S., R.J.v.G.); Institute for Social and Preventive Medicine, University of Bern, Bern, Switzerland (E.N., P.J.); CTU Bern, Bern University Hospital, Bern, Switzerland (E.N., P.J.); Academisch Medisch Centrum, Amsterdam, The Netherlands (K.T.K.); Catharina Ziekenhuis, Eindhoven, The Netherlands (J.J.K.); Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Trust, London, United...
  • Peter Jüni
    From the Erasmus Medical Centre–Thoraxcentre, Rotterdam, The Netherlands (J.L.G.-C., J.W., E.R., P.W.S., R.J.v.G.); Institute for Social and Preventive Medicine, University of Bern, Bern, Switzerland (E.N., P.J.); CTU Bern, Bern University Hospital, Bern, Switzerland (E.N., P.J.); Academisch Medisch Centrum, Amsterdam, The Netherlands (K.T.K.); Catharina Ziekenhuis, Eindhoven, The Netherlands (J.J.K.); Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Trust, London, United...
  • Evelyn Regar
    From the Erasmus Medical Centre–Thoraxcentre, Rotterdam, The Netherlands (J.L.G.-C., J.W., E.R., P.W.S., R.J.v.G.); Institute for Social and Preventive Medicine, University of Bern, Bern, Switzerland (E.N., P.J.); CTU Bern, Bern University Hospital, Bern, Switzerland (E.N., P.J.); Academisch Medisch Centrum, Amsterdam, The Netherlands (K.T.K.); Catharina Ziekenhuis, Eindhoven, The Netherlands (J.J.K.); Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Trust, London, United...
  • Patrick W. Serruys
    From the Erasmus Medical Centre–Thoraxcentre, Rotterdam, The Netherlands (J.L.G.-C., J.W., E.R., P.W.S., R.J.v.G.); Institute for Social and Preventive Medicine, University of Bern, Bern, Switzerland (E.N., P.J.); CTU Bern, Bern University Hospital, Bern, Switzerland (E.N., P.J.); Academisch Medisch Centrum, Amsterdam, The Netherlands (K.T.K.); Catharina Ziekenhuis, Eindhoven, The Netherlands (J.J.K.); Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Trust, London, United...

書誌事項

タイトル別名
  • Sequential Assessment With Optical Coherence Tomography
公開日
2012-02
DOI
  • 10.1161/circinterventions.111.965301
公開者
Ovid Technologies (Wolters Kluwer Health)

この論文をさがす

説明

<jats:sec> <jats:title>Background—</jats:title> <jats:p>The vascular tissue reaction to acute incomplete stent apposition (ISA) is not well known. The aim of this study was to characterize the vascular response to acute ISA in vivo and to look for predictors of incomplete healing.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods and Results—</jats:title> <jats:p>Optical coherence tomography studies of 66 stents of different designs, implanted in 43 patients enrolled in 3 randomized trials, were analyzed sequentially after implantation and at 6 to 13 months. Seventy-eight segments with acute ISA were identified in 36 of the patients and matched with the follow-up study by use of fiduciary landmarks. The morphological pattern of healing in the ISA segments was categorized as homogeneous, layered, crenellated, bridged, partially bridged, or bare, depending on the persistence of ISA and on the coverage. After 6 months, acute ISA volume decreased significantly, and 71.5% of the ISA segments were completely integrated into the vessel wall. Segments with acute ISA had higher risk of delayed coverage than well-apposed segments (relative risk 2.37, 95% confidence interval 2.01–2.78). Acute ISA size (estimated as ISA volume or maximum ISA distance per strut) was an independent predictor of ISA persistence and of delayed healing at follow-up.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions—</jats:title> <jats:p>Neointimal healing tends to reduce ISA, with the malapposed stent struts often integrated completely into the vessel wall, resulting in characteristic morphological patterns. Coverage of ISA segments is delayed with respect to well-apposed segments. The larger the acute ISA, the greater the likelihood of persistent malapposition at follow-up and delayed healing.</jats:p> </jats:sec> <jats:sec> <jats:title>Clinical Trial Registration—</jats:title> <jats:p> URL: <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://www.clinicaltrials.gov">http://www.clinicaltrials.gov</jats:ext-link> . Unique identifier: NCT00617084 and NCT00934752. </jats:p> </jats:sec>

収録刊行物

被引用文献 (9)*注記

もっと見る

詳細情報 詳細情報について

問題の指摘

ページトップへ