Mammalian synthetic biology for studying the cell

DOI PDF Web Site 被引用文献1件
  • Melina Mathur
    Department of Bioengineering, Stanford University, Stanford, CA 94305
  • Joy S. Xiang
    Department of Bioengineering, Stanford University, Stanford, CA 94305
  • Christina D. Smolke
    Department of Bioengineering, Stanford University, Stanford, CA 94305

書誌事項

公開日
2016-12-08
権利情報
  • http://www.rupress.org/terms/
  • https://creativecommons.org/licenses/by-nc-sa/4.0/
DOI
  • 10.1083/jcb.201611002
公開者
Rockefeller University Press

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説明

<jats:p>Synthetic biology is advancing the design of genetic devices that enable the study of cellular and molecular biology in mammalian cells. These genetic devices use diverse regulatory mechanisms to both examine cellular processes and achieve precise and dynamic control of cellular phenotype. Synthetic biology tools provide novel functionality to complement the examination of natural cell systems, including engineered molecules with specific activities and model systems that mimic complex regulatory processes. Continued development of quantitative standards and computational tools will expand capacities to probe cellular mechanisms with genetic devices to achieve a more comprehensive understanding of the cell. In this study, we review synthetic biology tools that are being applied to effectively investigate diverse cellular processes, regulatory networks, and multicellular interactions. We also discuss current challenges and future developments in the field that may transform the types of investigation possible in cell biology.</jats:p>

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