Spatiotemporal structure of cell fate decisions in murine neural crest

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  • Ruslan Soldatov
    Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA.
  • Marketa Kaucka
    Department of Molecular Neurosciences, Center for Brain Research, Medical University Vienna, 1090 Vienna, Austria.
  • Maria Eleni Kastriti
    Department of Molecular Neurosciences, Center for Brain Research, Medical University Vienna, 1090 Vienna, Austria.
  • Julian Petersen
    Department of Molecular Neurosciences, Center for Brain Research, Medical University Vienna, 1090 Vienna, Austria.
  • Tatiana Chontorotzea
    Department of Physiology and Pharmacology, Karolinska Institutet, 17177 Stockholm, Sweden.
  • Lukas Englmaier
    Department of Molecular Neurosciences, Center for Brain Research, Medical University Vienna, 1090 Vienna, Austria.
  • Natalia Akkuratova
    Department of Physiology and Pharmacology, Karolinska Institutet, 17177 Stockholm, Sweden.
  • Yunshi Yang
    Department of Physiology and Pharmacology, Karolinska Institutet, 17177 Stockholm, Sweden.
  • Martin Häring
    Department of Medical Biochemistry and Biophysics, Division of Molecular Neurobiology, Karolinska Institutet, 17177 Stockholm, Sweden.
  • Viacheslav Dyachuk
    Department of Neuroscience, Karolinska Institutet, 17177 Stockholm, Sweden.
  • Christoph Bock
    CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
  • Matthias Farlik
    CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
  • Michael L. Piacentino
    Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
  • Franck Boismoreau
    Institut de Biologie de l’ENS (IBENS), INSERM, CNRS, École Normale Supérieure, PSL Research University, 75005 Paris, France.
  • Markus M. Hilscher
    Department of Medical Biochemistry and Biophysics, Division of Molecular Neurobiology, Karolinska Institutet, 17177 Stockholm, Sweden.
  • Chika Yokota
    Science for Life Laboratory, Department of Biophysics and Biochemistry, Stockholm University, 17165 Solna, Sweden.
  • Xiaoyan Qian
    Science for Life Laboratory, Department of Biophysics and Biochemistry, Stockholm University, 17165 Solna, Sweden.
  • Mats Nilsson
    Science for Life Laboratory, Department of Biophysics and Biochemistry, Stockholm University, 17165 Solna, Sweden.
  • Marianne E. Bronner
    Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
  • Laura Croci
    San Raffaele Scientific Institute and Università Vita-Salute San Raffaele, 20132, Milan, Italy.
  • Wen-Yu Hsiao
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
  • David A. Guertin
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
  • Jean-Francois Brunet
    Institut de Biologie de l’ENS (IBENS), INSERM, CNRS, École Normale Supérieure, PSL Research University, 75005 Paris, France.
  • Gian Giacomo Consalez
    San Raffaele Scientific Institute and Università Vita-Salute San Raffaele, 20132, Milan, Italy.
  • Patrik Ernfors
    Department of Medical Biochemistry and Biophysics, Division of Molecular Neurobiology, Karolinska Institutet, 17177 Stockholm, Sweden.
  • Kaj Fried
    Department of Neuroscience, Karolinska Institutet, 17177 Stockholm, Sweden.
  • Peter V. Kharchenko
    Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA.
  • Igor Adameyko
    Department of Molecular Neurosciences, Center for Brain Research, Medical University Vienna, 1090 Vienna, Austria.

Description

<jats:title>Binary decisions refine fate decisions</jats:title> <jats:p> Neural crest cells develop into tissues ranging from craniofacial bones to peripheral neurons. Combining single-cell RNA sequencing with spatial transcriptomics, Soldatov <jats:italic>et al.</jats:italic> analyzed how neural crest cells in mouse embryos decide among the various fates available to them (see the Perspective by Mayor). These multipotent cells become biased toward a given fate early on and step through a progression of binary decisions as their fate is refined. Competing fate programs coexist until increased synchronization favors one and repression disfavors the other. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aas9536">eaas9536</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6444" page="937" related-article-type="in-this-issue" vol="364" xlink:href="10.1126/science.aax7917">937</jats:related-article> </jats:p>

Journal

  • Science

    Science 364 (6444), 2019-06-07

    American Association for the Advancement of Science (AAAS)

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