Interactive effects of inbreeding and endocrine disruption on reproduction in a model laboratory fish

DOI Web Site Web Site 被引用文献1件
  • Lisa K. Bickley
    University of Exeter, Biosciences, College of Life and Environmental Sciences Exeter UK
  • Andrew R. Brown
    University of Exeter, Biosciences, College of Life and Environmental Sciences Exeter UK
  • David J. Hosken
    University of Exeter, Biosciences, Centre for the Environment and Conservation Cornwall UK
  • Patrick B. Hamilton
    University of Exeter, Biosciences, College of Life and Environmental Sciences Exeter UK
  • Gareth Le Page
    University of Exeter, Biosciences, College of Life and Environmental Sciences Exeter UK
  • Gregory C. Paull
    University of Exeter, Biosciences, College of Life and Environmental Sciences Exeter UK
  • Stewart F. Owen
    AstraZeneca Safety, Health and Environment, Brixham Environmental Laboratory Brixham UK
  • Charles R. Tyler
    University of Exeter, Biosciences, College of Life and Environmental Sciences Exeter UK

書誌事項

公開日
2012-08-30
権利情報
  • http://creativecommons.org/licenses/by-nc/3.0/
DOI
  • 10.1111/j.1752-4571.2012.00288.x
公開者
Wiley

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説明

<jats:title>Abstract</jats:title><jats:p>Inbreeding depression is expected to be more severe in stressful environments. However, the extent to which inbreeding affects the vulnerability of populations to environmental stressors, such as chemical exposure, remains unresolved. Here we report on the combined impacts of inbreeding and exposure to an endocrine disrupting chemical (the fungicide clotrimazole) on zebrafish (<jats:italic>Danio rerio</jats:italic>). We show that whilst inbreeding can negatively affect reproductive traits, not all traits are affected equally. Inbreeding depression frequently only became apparent when fish were additionally stressed by chemical exposure. Embryo viability was significantly reduced in inbred exposed fish and there was a tendency for inbred males to sire fewer offspring when in direct competition with outbred individuals. Levels of plasma 11‐ketotestosterone, a key male sex hormone, showed substantial inbreeding depression that was unaffected by addition of the fungicide. In contrast, there was no effect of inbreeding or clotrimazole exposure on egg production. Overall, our data provide evidence that stress may amplify the effects of inbreeding on key reproductive traits, particularly those associated with male fitness. This may have important implications when considering the consequences of exposure to chemical pollutants on the fitness of wild populations.</jats:p>

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