Heterochronic parabiosis: historical perspective and methodological considerations for studies of aging and longevity

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  • Michael J. Conboy
    Department of Bioengineering University of California Berkeley CA 94720 USA
  • Irina M. Conboy
    Department of Bioengineering University of California Berkeley CA 94720 USA
  • Thomas A. Rando
    Paul F. Glenn Laboratories for the Biology of Aging and the Department of Neurology and Neurological Sciences Stanford University School of Medicine Stanford CA 94305 USA

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<jats:title>Summary</jats:title><jats:p>Pairing two animals in parabiosis to test for systemic or circulatory factors from one animal affecting the other animal has been used in scientific studies for at least 150 years. These studies have led to advances in fields as diverse as endocrinology, immunology, and oncology. A variation on the technique, heterochronic parabiosis, whereby two animals of different ages are joined to test for systemic regulators of aspects of aging or age‐related diseases also has almost a century‐long scientific history. In this review, we focus on the history of heterochronic parabiosis, methodological considerations and caveats, and the major advances that have emerged from those studies, including recent advances in our understanding of stem cell aging.</jats:p>

Journal

  • Aging Cell

    Aging Cell 12 (3), 525-530, 2013-04-10

    Wiley

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