Magnetic Resonance Imaging of Cerebral Malaria Patients Reveals Distinct Pathogenetic Processes in Different Parts of the Brain
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- Sanjib Mohanty
- Center for the Study of Complex Malaria in India, Ispat General Hospital, Rourkela, Odisha, India
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- Laura A. Benjamin
- Brain Infections Group, Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom
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- Megharay Majhi
- Department of Radiology, Ispat General Hospital, Rourkela, Odisha, India
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- Premanand Panda
- Department of Radiology, Ispat General Hospital, Rourkela, Odisha, India
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- Sam Kampondeni
- Department of Radiology, Queen Elizabeth Central Hospital, Blantyre, Malawi
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- Praveen K. Sahu
- Center for the Study of Complex Malaria in India, Ispat General Hospital, Rourkela, Odisha, India
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- Akshaya Mohanty
- Infectious Diseases Biology Unit, Institute of Life Sciences, Bhubaneswar, Odisha, India
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- Kishore C. Mahanta
- Department of Intensive Care, Ispat General Hospital, Rourkela, Odisha, India
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- Rajyabardhan Pattnaik
- Department of Intensive Care, Ispat General Hospital, Rourkela, Odisha, India
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- Rashmi R. Mohanty
- Department of Ophthalmology, Ispat General Hospital, Rourkela, Odisha, India
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- Sonia Joshi
- Department of Ophthalmology, Ispat General Hospital, Rourkela, Odisha, India
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- Anita Mohanty
- Department of Intensive Care, Ispat General Hospital, Rourkela, Odisha, India
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- Ian W. Turnbull
- North Manchester General Hospital, Manchester, United Kingdom
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- Arjen M. Dondorp
- Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
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- Terrie E. Taylor
- Department of Osteopathic Medical Specialties, College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan, USA
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- Samuel C. Wassmer
- Department of Immunology and Infection, London School of Hygiene & Tropical Medicine, London, United Kingdom
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- Ira J. Blader
- editor
書誌事項
- 公開日
- 2017-06-28
- 権利情報
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- http://creativecommons.org/licenses/by/4.0/
- https://journals.asm.org/non-commercial-tdm-license
- DOI
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- 10.1128/msphere.00193-17
- 公開者
- American Society for Microbiology
説明
<jats:p> The pathophysiology and molecular mechanisms underlying cerebral malaria (CM) are still poorly understood. Recent neuroimaging studies demonstrated that brain swelling is a common feature in CM and a major contributor to death in pediatric patients. Consequently, determining the precise mechanisms responsible for this swelling could open new adjunct therapeutic avenues in CM patients. Using an MRI scanner with a higher resolution than the ones used in previous reports, we identified two distinct origins of brain swelling in both adult and pediatric patients from India, occurring in distinct parts of the brain. Our results support the hypothesis that both endothelial dysfunction and microvascular obstruction by <jats:named-content content-type="genus-species">Plasmodium falciparum</jats:named-content> -infected erythrocytes make independent contributions to the pathogenesis of CM, providing opportunities for novel therapeutic interventions. </jats:p>
収録刊行物
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- mSphere
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mSphere 2 (3), 2017-06-28
American Society for Microbiology
