Direct Interaction of <i>Arabidopsis</i> Cryptochromes with COP1 in Light Control Development
-
- Haiyang Wang
- Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520, USA.
-
- Li-Geng Ma
- Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520, USA.
-
- Jin-Ming Li
- Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520, USA.
-
- Hong-Yu Zhao
- Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520, USA.
-
- Xing Wang Deng
- Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520, USA.
書誌事項
- 公開日
- 2001-10-05
- DOI
-
- 10.1126/science.1063630
- 公開者
- American Association for the Advancement of Science (AAAS)
この論文をさがす
説明
<jats:p> <jats:italic>Arabidopsis</jats:italic> seedling photomorphogenesis involves two antagonistically acting components, COP1 and HY5. COP1 specifically targets HY5 for degradation via the 26 <jats:italic>S</jats:italic> proteasome in the dark through their direct physical interaction. Little is known regarding how light signals perceived by photoreceptors are transduced to regulate COP1. <jats:italic>Arabidopsis</jats:italic> has two related cryptochromes (cry1 and cry2) mediating various blue/ultraviolet-A light responses. Here we show that both photoactivated cryptochromes repress COP1 activity through a direct protein-protein contact and that this direct regulation is primarily responsible for the cryptochrome-mediated blue light regulation of seedling photomorphogenic development and genome expression profile. </jats:p>
収録刊行物
-
- Science
-
Science 294 (5540), 154-158, 2001-10-05
American Association for the Advancement of Science (AAAS)
