Stem cells with decellularized liver scaffolds in liver regeneration and their potential clinical applications

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  • Qian Zhou
    State Key Laboratory for Diagnosis and Treatment of Infectious Diseases Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases The First Affiliated Hospital School of Medicine Zhejiang University 79 Qingchun Rd. Hangzhou 310003 China
  • Lanjuan Li
    State Key Laboratory for Diagnosis and Treatment of Infectious Diseases Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases The First Affiliated Hospital School of Medicine Zhejiang University 79 Qingchun Rd. Hangzhou 310003 China
  • Jun Li
    State Key Laboratory for Diagnosis and Treatment of Infectious Diseases Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases The First Affiliated Hospital School of Medicine Zhejiang University 79 Qingchun Rd. Hangzhou 310003 China

書誌事項

公開日
2014-05-30
権利情報
  • http://onlinelibrary.wiley.com/termsAndConditions#vor
DOI
  • 10.1111/liv.12581
公開者
Wiley

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<jats:title>Abstract</jats:title><jats:p>End‐stage hepatic failure is a potentially life‐threatening condition for which orthotopic liver transplantation (<jats:styled-content style="fixed-case">OLT</jats:styled-content>) is the only effective treatment. However, a shortage of available donor organs for transplantation each year results in the death of many patients waiting for liver transplantation. Cell‐based therapies and hepatic tissue engineering have been considered as alternatives to liver transplantation. However, primary hepatocyte transplantation has rarely produced therapeutic effects because mature hepatocytes cannot be effectively expanded <jats:italic>in vitro</jats:italic>, and the availability of hepatocytes is often limited by shortages of donor organs. Decellularization is an attractive technique for scaffold preparation in stem cell‐based liver engineering, as the resulting material can potentially retain the liver architecture, native vessel network and specific extracellular matrix (<jats:styled-content style="fixed-case">ECM</jats:styled-content>). Thus, the reconstruction of functional and practical liver tissue using decellularized scaffolds becomes possible. This review focuses on the current understanding of liver tissue engineering, whole‐organ liver decellularization techniques, cell sources for recellularization and potential clinical applications and challenges.</jats:p>

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