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- Anouk K. Gloudemans
- Department of Pulmonology, Erasmus Medical Center, Rotterdam, The Netherlands
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- Bart N. Lambrecht
- Department of Pulmonology, Erasmus Medical Center, Rotterdam, The Netherlands
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- Hermelijn H. Smits
- Leiden Immunoparasitology Group, Department of Parasitology, Leiden University Medical Center, Albinusdreef 2, P4-37A, 2333 ZA Leiden, The Netherlands
書誌事項
- 公開日
- 2013
- 権利情報
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- http://creativecommons.org/licenses/by/3.0/
- DOI
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- 10.1155/2013/542091
- 公開者
- Hindawi Limited
この論文をさがす
説明
<jats:p>Allergic asthma is characterized by bronchial hyperresponsiveness, a defective barrier function, and eosinophilic lower airway inflammation in response to allergens. The inflammation is dominated by Th2 cells and IgE molecules and supplemented with Th17 cells in severe asthma. In contrast, in healthy individuals, allergen-specific IgA and IgG4 molecules are found but no IgE, and their T cells fail to proliferate in response to allergens, probably because of the development of regulatory processes that actively suppress responses to allergens. The presence of allergen-specific secretory IgA has drawn little attention so far, although a few epidemiological studies point at a reverse association between IgA levels and the incidence of allergic airway disease. This review highlights the latest literature on the role of mucosal IgA in protection against allergic airway disease, the mechanisms described to induce secretory IgA, and the role of (mucosal) dendritic cells in this process. Finally, we discuss how this information can be used to translate into the development of new therapies for allergic diseases based on, or supplemented with, IgA boosting strategies.</jats:p>
収録刊行物
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- Clinical and Developmental Immunology
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Clinical and Developmental Immunology 2013 1-12, 2013
Hindawi Limited
