<i>In vitro</i> and <i>in vivo</i> studies on bioabsorbable ultra‐high‐strength poly(<scp>L</scp>‐lactide) rods
書誌事項
- 公開日
- 1992-12
- 権利情報
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- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
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- 10.1002/jbm.820261203
- 公開者
- Wiley
この論文をさがす
説明
<jats:title>Abstract</jats:title><jats:p>Ultra‐high‐strength poly(<jats:sc>L</jats:sc>‐lactide) (PLLA) rods were fabricated using a drawing technique. Rods with a diameter of 3.2 mm and a draw ratio of 2.5:1 showed initial bending strength and modulus values of 240 MPa and 13 GPa, respectively. The purpose of this study was to investigate the <jats:italic>in vitro</jats:italic> and <jats:italic>in vivo</jats:italic> degradation of PLLA rods with a draw ratio of 2.5:1. The greater the rod diameter, the longer the bending strength was maintained in phosphate buffered saline at 37°C. The bending strength retention of rods (diam. 3.2 mm) implanted in the subcutis of rabbits was almost equal to that of rods in the <jats:italic>in vitro</jats:italic> study, while those rods implanted in the medullary cavity of rabbit femora showed a slightly lower bending strength retention. Molecular weight was reduced to the greatest extent in the medullary cavity, followed by in the subcutis and <jats:italic>in vitro</jats:italic>. The weight of PLLA rods in the medullary cavity was reduced by 22% at 52 weeks and by 70% at 78 weeks after implantation. Histologically, no inflammatory or foreign body reaction was observed in the medullary cavity for 52 weeks. The drawn PLLA rods maintained a bending strength exceeding that of human cortical bone in the medullary canal for a period of 8 weeks, suggesting that the drawn PLLA rods may be useful in the repair of fractured human bones. © 1992 John Wiley & Sons, Inc.</jats:p>
収録刊行物
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- Journal of Biomedical Materials Research
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Journal of Biomedical Materials Research 26 (12), 1553-1567, 1992-12
Wiley