Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies
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- Alina Baum
- Regeneron Pharmaceuticals Inc., Tarrytown, NY 10591, USA.
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- Benjamin O. Fulton
- Regeneron Pharmaceuticals Inc., Tarrytown, NY 10591, USA.
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- Elzbieta Wloga
- Regeneron Pharmaceuticals Inc., Tarrytown, NY 10591, USA.
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- Richard Copin
- Regeneron Pharmaceuticals Inc., Tarrytown, NY 10591, USA.
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- Kristen E. Pascal
- Regeneron Pharmaceuticals Inc., Tarrytown, NY 10591, USA.
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- Vincenzo Russo
- Regeneron Pharmaceuticals Inc., Tarrytown, NY 10591, USA.
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- Stephanie Giordano
- Regeneron Pharmaceuticals Inc., Tarrytown, NY 10591, USA.
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- Kathryn Lanza
- Regeneron Pharmaceuticals Inc., Tarrytown, NY 10591, USA.
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- Nicole Negron
- Regeneron Pharmaceuticals Inc., Tarrytown, NY 10591, USA.
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- Min Ni
- Regeneron Pharmaceuticals Inc., Tarrytown, NY 10591, USA.
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- Yi Wei
- Regeneron Pharmaceuticals Inc., Tarrytown, NY 10591, USA.
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- Gurinder S. Atwal
- Regeneron Pharmaceuticals Inc., Tarrytown, NY 10591, USA.
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- Andrew J. Murphy
- Regeneron Pharmaceuticals Inc., Tarrytown, NY 10591, USA.
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- Neil Stahl
- Regeneron Pharmaceuticals Inc., Tarrytown, NY 10591, USA.
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- George D. Yancopoulos
- Regeneron Pharmaceuticals Inc., Tarrytown, NY 10591, USA.
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- Christos A. Kyratsous
- Regeneron Pharmaceuticals Inc., Tarrytown, NY 10591, USA.
説明
<jats:title>An antibody cocktail against SARS-CoV-2</jats:title> <jats:p> There is an urgent focus on antibodies that target the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral spike and prevent the virus from entering host cells. Hansen <jats:italic>et al.</jats:italic> generated a large panel of antibodies against the spike protein from humanized mice and recovered patients. From this panel, they identified several neutralizing antibodies, including pairs that do not compete for binding to the receptor binding domain. Baum <jats:italic>et al.</jats:italic> focused in on four of these antibodies. All four are effective against known spike variants. However, by growing a pseudovirus that expresses the spike in the presence of individual antibodies, the authors were able to select for spike mutants resistant to that antibody. In contrast, escape mutants are not selected when pseudovirus is grown in the presence of pairs of antibodies that either do not compete or only partially compete for binding to the RBD. Such a pair might be used in a therapeutic antibody cocktail. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6506" page="1010" related-article-type="in-this-issue" vol="369" xlink:href="10.1126/science.abd0827">1010</jats:related-article> , p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6506" page="1014" related-article-type="in-this-issue" vol="369" xlink:href="10.1126/science.abd0831">1014</jats:related-article> </jats:p>
収録刊行物
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- Science
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Science 369 (6506), 1014-1018, 2020-08-21
American Association for the Advancement of Science (AAAS)