Cutting Edge: Lymphatic Vessels, Not Blood Vessels, Primarily Mediate Immune Rejections After Transplantation

DOI PDF 被引用文献8件
  • Tina Dietrich
    Department of Ophthalmology, University of Erlangen-Nürnberg , Erlangen
  • Felix Bock
    Department of Ophthalmology, University of Erlangen-Nürnberg , Erlangen
  • Don Yuen
    Center for Eye Disease and Development, Program in Vision Science and School of Optometry, University of California , Berkeley, Berkeley, CA 94701
  • Deniz Hos
    Department of Ophthalmology, University of Erlangen-Nürnberg , Erlangen
  • Björn O Bachmann
    Department of Ophthalmology, University of Erlangen-Nürnberg , Erlangen
  • Grit Zahn
    Jerini AG , Berlin,
  • Stanley Wiegand
    Regeneron Pharmaceuticals , Tarrytown, NY 10591
  • Lu Chen
    Center for Eye Disease and Development, Program in Vision Science and School of Optometry, University of California , Berkeley, Berkeley, CA 94701
  • Claus Cursiefen
    Department of Ophthalmology, University of Erlangen-Nürnberg , Erlangen

書誌事項

公開日
2009-12-27
権利情報
  • https://academic.oup.com/pages/standard-publication-reuse-rights
DOI
  • 10.4049/jimmunol.0903180
公開者
Oxford University Press (OUP)

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説明

<jats:title>Abstract</jats:title> <jats:p>The purpose of this study was to determine the relative importance of blood vessels (hemangiogenesis) versus lymphatic vessels (lymphangiogenesis) in mediating immunological responses after transplantation. Using the murine model of corneal transplantation, graft survival was compared in differentially prevascularized and avascular recipient beds. Donor corneas (C57BL/6) were transplanted into uninflamed or inflamed avascular, prehemvascularized only or prehemvascularized and prelymphvascularized recipient murine eyes (BALB/C). Selective inhibition of lymphangiogenesis was achieved using antivascular endothelial growth factor receptor 3 Abs and anti-integrin α5 small molecules. Grafts placed into only prehemvascularized recipient beds had a similarly good graft survival compared with grafts placed into completely avascular, normal recipients, whereas the pre-existence of lymphatic vessels significantly deteriorated corneal graft survival (p &lt; 0.05). Lymphatic vessels seem to contribute significantly to graft rejection after (corneal) transplantation. That may allow for selective, temporary, perioperative antilymphangiogenic treatment to promote graft survival without affecting blood vessels, even after solid organ transplantation.</jats:p>

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