Oxidative stress stimulates α-tocopherol transfer protein in human trophoblast tumor cells BeWo

DOI Web Site Web Site 被引用文献3件
  • Ronny P. Etzl
  • Thomas Vrekoussis
    Department of Obstetrics and Gynaecology, Ludwig Maximilians University of Munich, Maistrasse 11, D-80337 Munich, Germany
  • Christina Kuhn
    Department of Obstetrics and Gynaecology, Ludwig Maximilians University of Munich, Maistrasse 11, D-80337 Munich, Germany
  • Sandra Schulze
    Department of Obstetrics and Gynaecology, Ludwig Maximilians University of Munich, Maistrasse 11, D-80337 Munich, Germany
  • Johannes M. Pöschl
    Division of Neonatology, Department of Pediatrics, University of Heidelberg, INF 150, D-69120 Heidelberg, Germany
  • Antonis Makrigiannakis
    Department of Obstetrics and Gynaecology, Medical School, University of Crete, Iraklion, Crete, Greece
  • Udo Jeschke
    Department of Obstetrics and Gynaecology, Ludwig Maximilians University of Munich, Maistrasse 11, D-80337 Munich, Germany
  • Daisy E. Rotzoll

書誌事項

公開日
2012-02-10
DOI
  • 10.1515/jpm-2011-0307
公開者
Walter de Gruyter GmbH

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<jats:title>Abstract</jats:title> <jats:p>α-Tocopherol transfer protein (α-TTP) has been identified as the major intracellular transport protein for the antioxidant vitamin E (α-tocopherol). Expression of α-TTP on the reproductive system has been described both in mouse uterus and lately in the human placenta. The aim of this study was to clarify if placental expression of α-TTP can be modified by substances causing oxidative reactions. The human choriocarcinoma cell line BeWo was, therefore, treated with two known pro-oxidants. α-TTP expression was determined with immunocytochemistry and evaluated by applying a semiquantitative score. The presence of pro-oxidants in BeWo cells induced α-TTP expression. We thus hypothesize that stimulation of α-TTP expression by oxidative stress, as this was induced by pro-oxidants, could be part of an antioxidant process occurring in the placenta in the aim of enhancing the supply of α-tocopherol. This process could occur both in normal pregnancies, as well as in pregnancy disorders presented with intensified oxidative stress. In that view, this model is proposed for further oxidative stress studies on trophoblast and placenta, on the grounds of clarifying the role of α-tocopherol in pregnancy physiology and pathophysiology.</jats:p>

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