Identification of Novel Inhibitors of the Transforming Growth Factor β1 (TGF-β1) Type 1 Receptor (ALK5)

  • James F. Callahan
    Department of Medicinal Chemistry, GlaxoSmithKline Pharmaceuticals, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, Departments of Medicinal Chemistry, Renal Pharmacology, Protein Biochemistry, and Gene Expression Sciences, GlaxoSmithKline Pharmaceuticals, 709 Swedeland Road, King of Prussia, Pennsylvania 19406, and Department of Medicinal Chemistry, New Frontiers Science Park (North), Coldharbour Road, Harlow, Essex CM19 5AD, England
  • Joelle L. Burgess
    Department of Medicinal Chemistry, GlaxoSmithKline Pharmaceuticals, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, Departments of Medicinal Chemistry, Renal Pharmacology, Protein Biochemistry, and Gene Expression Sciences, GlaxoSmithKline Pharmaceuticals, 709 Swedeland Road, King of Prussia, Pennsylvania 19406, and Department of Medicinal Chemistry, New Frontiers Science Park (North), Coldharbour Road, Harlow, Essex CM19 5AD, England
  • James A. Fornwald
    Department of Medicinal Chemistry, GlaxoSmithKline Pharmaceuticals, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, Departments of Medicinal Chemistry, Renal Pharmacology, Protein Biochemistry, and Gene Expression Sciences, GlaxoSmithKline Pharmaceuticals, 709 Swedeland Road, King of Prussia, Pennsylvania 19406, and Department of Medicinal Chemistry, New Frontiers Science Park (North), Coldharbour Road, Harlow, Essex CM19 5AD, England
  • Laramie M. Gaster
    Department of Medicinal Chemistry, GlaxoSmithKline Pharmaceuticals, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, Departments of Medicinal Chemistry, Renal Pharmacology, Protein Biochemistry, and Gene Expression Sciences, GlaxoSmithKline Pharmaceuticals, 709 Swedeland Road, King of Prussia, Pennsylvania 19406, and Department of Medicinal Chemistry, New Frontiers Science Park (North), Coldharbour Road, Harlow, Essex CM19 5AD, England
  • John D. Harling
    Department of Medicinal Chemistry, GlaxoSmithKline Pharmaceuticals, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, Departments of Medicinal Chemistry, Renal Pharmacology, Protein Biochemistry, and Gene Expression Sciences, GlaxoSmithKline Pharmaceuticals, 709 Swedeland Road, King of Prussia, Pennsylvania 19406, and Department of Medicinal Chemistry, New Frontiers Science Park (North), Coldharbour Road, Harlow, Essex CM19 5AD, England
  • Frank P. Harrington
    Department of Medicinal Chemistry, GlaxoSmithKline Pharmaceuticals, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, Departments of Medicinal Chemistry, Renal Pharmacology, Protein Biochemistry, and Gene Expression Sciences, GlaxoSmithKline Pharmaceuticals, 709 Swedeland Road, King of Prussia, Pennsylvania 19406, and Department of Medicinal Chemistry, New Frontiers Science Park (North), Coldharbour Road, Harlow, Essex CM19 5AD, England
  • Jag Heer
    Department of Medicinal Chemistry, GlaxoSmithKline Pharmaceuticals, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, Departments of Medicinal Chemistry, Renal Pharmacology, Protein Biochemistry, and Gene Expression Sciences, GlaxoSmithKline Pharmaceuticals, 709 Swedeland Road, King of Prussia, Pennsylvania 19406, and Department of Medicinal Chemistry, New Frontiers Science Park (North), Coldharbour Road, Harlow, Essex CM19 5AD, England
  • Chet Kwon
    Department of Medicinal Chemistry, GlaxoSmithKline Pharmaceuticals, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, Departments of Medicinal Chemistry, Renal Pharmacology, Protein Biochemistry, and Gene Expression Sciences, GlaxoSmithKline Pharmaceuticals, 709 Swedeland Road, King of Prussia, Pennsylvania 19406, and Department of Medicinal Chemistry, New Frontiers Science Park (North), Coldharbour Road, Harlow, Essex CM19 5AD, England
  • Ruth Lehr
    Department of Medicinal Chemistry, GlaxoSmithKline Pharmaceuticals, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, Departments of Medicinal Chemistry, Renal Pharmacology, Protein Biochemistry, and Gene Expression Sciences, GlaxoSmithKline Pharmaceuticals, 709 Swedeland Road, King of Prussia, Pennsylvania 19406, and Department of Medicinal Chemistry, New Frontiers Science Park (North), Coldharbour Road, Harlow, Essex CM19 5AD, England
  • A. Mathur
    Department of Medicinal Chemistry, GlaxoSmithKline Pharmaceuticals, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, Departments of Medicinal Chemistry, Renal Pharmacology, Protein Biochemistry, and Gene Expression Sciences, GlaxoSmithKline Pharmaceuticals, 709 Swedeland Road, King of Prussia, Pennsylvania 19406, and Department of Medicinal Chemistry, New Frontiers Science Park (North), Coldharbour Road, Harlow, Essex CM19 5AD, England
  • Barbara A. Olson
    Department of Medicinal Chemistry, GlaxoSmithKline Pharmaceuticals, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, Departments of Medicinal Chemistry, Renal Pharmacology, Protein Biochemistry, and Gene Expression Sciences, GlaxoSmithKline Pharmaceuticals, 709 Swedeland Road, King of Prussia, Pennsylvania 19406, and Department of Medicinal Chemistry, New Frontiers Science Park (North), Coldharbour Road, Harlow, Essex CM19 5AD, England
  • Joseph Weinstock
    Department of Medicinal Chemistry, GlaxoSmithKline Pharmaceuticals, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, Departments of Medicinal Chemistry, Renal Pharmacology, Protein Biochemistry, and Gene Expression Sciences, GlaxoSmithKline Pharmaceuticals, 709 Swedeland Road, King of Prussia, Pennsylvania 19406, and Department of Medicinal Chemistry, New Frontiers Science Park (North), Coldharbour Road, Harlow, Essex CM19 5AD, England
  • Nicholas J. Laping
    Department of Medicinal Chemistry, GlaxoSmithKline Pharmaceuticals, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, Departments of Medicinal Chemistry, Renal Pharmacology, Protein Biochemistry, and Gene Expression Sciences, GlaxoSmithKline Pharmaceuticals, 709 Swedeland Road, King of Prussia, Pennsylvania 19406, and Department of Medicinal Chemistry, New Frontiers Science Park (North), Coldharbour Road, Harlow, Essex CM19 5AD, England

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