Expression and inducibility in Staphylococcus aureus of the mecA gene, which encodes a methicillin-resistant S. aureus-specific penicillin-binding protein
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- K Ubukata
- Department of Clinical Pathology, Teikyo University School of Medicine, Tokyo, Japan.
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- R Nonoguchi
- Department of Clinical Pathology, Teikyo University School of Medicine, Tokyo, Japan.
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- M Matsuhashi
- Department of Clinical Pathology, Teikyo University School of Medicine, Tokyo, Japan.
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- M Konno
- Department of Clinical Pathology, Teikyo University School of Medicine, Tokyo, Japan.
書誌事項
- 公開日
- 1989-05
- 権利情報
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- https://journals.asm.org/non-commercial-tdm-license
- DOI
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- 10.1128/jb.171.5.2882-2885.1989
- 公開者
- American Society for Microbiology
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説明
<jats:p>A beta-lactam-sensitive strain of Staphylococcus aureus could be converted to methicillin resistance by the introduction of a plasmid carrying the 4.3-kilobase HindIII chromosomal DNA fragment which encoded the mecA gene from a methicillin-resistant S. aureus. Transformant cells produced methicillin-resistant S. aureus-specific penicillin-binding protein constitutively, and additional insertion of an inducible penicillinase plasmid caused production of the pencillin-binding protein to become inducible.</jats:p>
収録刊行物
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- Journal of Bacteriology
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Journal of Bacteriology 171 (5), 2882-2885, 1989-05
American Society for Microbiology