De novo formation of caveolae in lymphocytes by expression of VIP21-caveolin.

DOI Web Site 被引用文献12件
  • A M Fra
    European Molecular Biology Laboratory, Heidelberg, Germany.
  • E Williamson
    European Molecular Biology Laboratory, Heidelberg, Germany.
  • K Simons
    European Molecular Biology Laboratory, Heidelberg, Germany.
  • R G Parton
    European Molecular Biology Laboratory, Heidelberg, Germany.

書誌事項

公開日
1995-09-12
DOI
  • 10.1073/pnas.92.19.8655
公開者
Proceedings of the National Academy of Sciences

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説明

<jats:p>Caveolae are plasma membrane invaginations, which have been implicated in endothelial transcytosis, endocytosis, potocytosis, and signal transduction. In addition to their well-defined morphology, caveolae are characterized by the presence of an integral membrane protein termed VIP21-caveolin. We have recently observed that lymphocytes have no detectable VIP21-caveolin and lack plasma membrane invaginations resembling caveolae. Here we transiently express VIP21-caveolin in a lymphocyte cell line using the Semliki Forest virus expression system and show de novo formation of plasma membrane invaginations containing VIP21-caveolin. These invaginations appear homogeneous in size and morphologically indistinguishable from caveolae of nonlymphoid cells. Moreover, the glycosylphosphatidylinositol-anchored protein. Thy1, patched by antibodies, redistributes to the newly formed caveolae. Our results show that VIP21-caveolin is a key structural component required for caveolar biogenesis.</jats:p>

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