MiR-139-5p is Increased in the Peripheral Blood of Patients with Prostate Cancer

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書誌事項

公開日
2016
権利情報
  • https://creativecommons.org/licenses/by-nc-nd/4.0/
  • https://creativecommons.org/licenses/by-nc-nd/4.0/
DOI
  • 10.1159/000447819
公開者
S. Karger AG

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説明

<jats:p>Background: Emerging evidence suggested that microRNAs (miRNAs) play a causal role in cancer tumorigenesis. Aberrant expression of miRNA (miR)-139-5p has been observed in various types of cancers. The present study evaluated the relationship between miR-139-5p expression levels and prostate cancer (PCa), to assess the feasibility of using peripheral blood miR-139-5p as a potential non-invasive biomarker for PCa. Methods: Total RNA was extracted from peripheral whole blood samples from 45 PCa patients, 45 benign prostatic hyperplasia (BPH) patients and 50 healthy controls (HC). The expression of miR-139-5p was assessed by reverse transcription quantitative polymerase chain reaction. Results: MiR-139-5p in peripheral blood was significantly higher in PCa patients than in patients with BPH and HC individuals (P<0.001). Higher miR-139-5p expression was observed to be associated with certain clinicopathological parameters, including PSA>20ng/ml (P<0.05), pathological tumor stage 3/4 (P<0.05) and Gleason score >7 (P<0.01). A receiver operating characteristic (ROC) curve analysis revealed that miR-139-5p distinguished PCa patients from BPH patients [area under the curve (AUC), 0.936; 95% CI, 0.878-0.993; P<0.001]. Conclusions: Peripheral blood miR-139-5p may be utilized as a potential novel non-invasive biomarker for PCa screening.</jats:p>

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