New synthetic inhibitors of C1r̄, C1 esterase, thrombin, plasmin, kallikrein and trypsin
説明
p-Guanidinobenzoate derivates were prepared and their inhibitory effects on trypsin, plasmin, pancreatic kallikrein, plasma kallikrein, thrombin, C1r and C1 esterase were examined. Among the various inhibitors tested, 6'-amidino-2-naphthyl-4-guanidinobenzoate dihydrochloride, 4-(beta-amidinoethenyl)phenyl-4-guanidinobenzoate dimethanesulfonate and 4-amidino-2-benzoylphenyl-4-guanidinobenzoate dimethanesulfonate were the most effective inhibitors of trypsin, plasmin, pancreatic kallikrein. plasma kallikrein and thrombin and they strongly inhibited the esterolytic activities of C1r and C1 esterase, and then strongly inhibited complement-mediated hemolysis.
収録刊行物
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- Biochimica et Biophysica Acta (BBA) - Enzymology
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Biochimica et Biophysica Acta (BBA) - Enzymology 661 (2), 342-345, 1981-10
Elsevier BV
