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- Helen L. Lightfoot
- Department of Chemistry and Applied Biosciences Institute of Pharmaceutical Sciences ETH Zurich Switzerland
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- Timo Hagen
- Department of Chemistry and Applied Biosciences Institute of Pharmaceutical Sciences ETH Zurich Switzerland
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- Natalie J. Tatum
- Newcastle Cancer Centre Northern Institute for Cancer Research Medical School Newcastle University Newcastle upon Tyne UK
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- Jonathan Hall
- Department of Chemistry and Applied Biosciences Institute of Pharmaceutical Sciences ETH Zurich Switzerland
説明
<jats:p>G‐quadruplexes are secondary structures formed in G‐rich sequences in <jats:styled-content style="fixed-case">DNA</jats:styled-content> and <jats:styled-content style="fixed-case">RNA</jats:styled-content>. Considerable research over the past three decades has led to in‐depth insight into these unusual structures in <jats:styled-content style="fixed-case">DNA</jats:styled-content>. Since the more recent exploration into <jats:styled-content style="fixed-case">RNA</jats:styled-content> G‐quadruplexes, such structures have demonstrated their <jats:italic>in cellulo</jats:italic> existence, function and roles in pathology. In comparison to Watson‐Crick‐based secondary structures, most G‐quadruplexes display highly redundant structural characteristics. However, numerous reports of G‐quadruplex motifs/structures with unique features (e.g. bulges, long loops, vacancy) have recently surfaced, expanding the repertoire of G‐quadruplex scaffolds. This review addresses G‐quadruplex formation and structure, including recent reports of non‐canonical G‐quadruplex structures. Improved methods of detection will likely further expand this collection of novel structures and ultimately change the face of quadruplex‐<jats:styled-content style="fixed-case">RNA</jats:styled-content> targeting as a therapeutic strategy.</jats:p>
収録刊行物
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- FEBS Letters
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FEBS Letters 593 (16), 2083-2102, 2019-07-30
Wiley