Small cell lung cancer and interstitial pneumonia associated with anti‐transcriptional intermediary factor‐1γ‐positive dermatomyositis

DOI Web Site Web Site Web Site 被引用文献1件 参考文献5件
  • Toshio Kato
    Department of Respiratory Medicine and Allergology Aichi Medical University Nagakute Japan
  • Satoru Ito
    Department of Respiratory Medicine and Allergology Aichi Medical University Nagakute Japan
  • Toyonori Tsuzuki
    Department of Surgical Pathology Aichi Medical University Nagakute Japan
  • Daisuke Watanabe
    Department of Dermatology Aichi Medical University Nagakute Japan
  • Akihito Kubo
    Department of Respiratory Medicine and Allergology Aichi Medical University Nagakute Japan
  • Etsuro Yamaguchi
    Department of Respiratory Medicine and Allergology Aichi Medical University Nagakute Japan

この論文をさがす

説明

<jats:p>Antibodies to transcriptional intermediary factor‐1γ (TIF‐1γ) are strongly associated with malignancy in patients with dermatomyositis but a relatively low risk for interstitial lung disease. We report the case of a 68‐year‐old female with small cell lung cancer (SCLC) and interstitial pneumonia who was diagnosed first with dermatomyositis positive for serum anti‐TIF‐1γ antibodies. Because interstitial pneumonia co‐existed, she was treated with carboplatin and etoposide without radiotherapy. A significant improvement in skin disease and SCLC was seen in response to chemotherapy. The levels of anti‐TIF‐1γ antibodies were also decreased by chemotherapy. Her interstitial pneumonia was mild with normal pulmonary function and did not change during the observation period. This is the first report of dermatomyositis associated with anti‐TIF‐1γ antibodies co‐existing with interstitial pneumonia and SCLC. Because cases with interstitial pneumonia in cancer‐associated dermatomyositis positive for anti‐TIF‐1γ antibodies are few in number, further studies are necessary to elucidate the clinical features.</jats:p>

収録刊行物

被引用文献 (1)*注記

もっと見る

参考文献 (5)*注記

もっと見る

関連プロジェクト

もっと見る

キーワード

問題の指摘

ページトップへ