CD36 expression on oral squamous cell carcinoma cells correlates with enhanced proliferation and migratory activity
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- Kotaro Sakurai
- Department of Oral and Maxillofacial Surgery Graduate School of Medicine and Pharmaceutical Sciences for Research University of Toyama Toyama city Japan
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- Kei Tomihara
- Department of Oral and Maxillofacial Surgery Graduate School of Medicine and Pharmaceutical Sciences for Research University of Toyama Toyama city Japan
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- Manabu Yamazaki
- Division of Oral Pathology Department of Tissue Regeneration and Reconstruction Graduate School of Medical and Dental Sciences Niigata University Niigata city Japan
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- Wataru Heshiki
- Department of Oral and Maxillofacial Surgery Graduate School of Medicine and Pharmaceutical Sciences for Research University of Toyama Toyama city Japan
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- Rohan Moniruzzaman
- Department of Oral and Maxillofacial Surgery Graduate School of Medicine and Pharmaceutical Sciences for Research University of Toyama Toyama city Japan
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- Katsuhisa Sekido
- Department of Oral and Maxillofacial Surgery Graduate School of Medicine and Pharmaceutical Sciences for Research University of Toyama Toyama city Japan
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- Hidetake Tachinami
- Department of Oral and Maxillofacial Surgery Graduate School of Medicine and Pharmaceutical Sciences for Research University of Toyama Toyama city Japan
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- Atsushi Ikeda
- Department of Oral and Maxillofacial Surgery Graduate School of Medicine and Pharmaceutical Sciences for Research University of Toyama Toyama city Japan
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- Shuichi Imaue
- Department of Oral and Maxillofacial Surgery Graduate School of Medicine and Pharmaceutical Sciences for Research University of Toyama Toyama city Japan
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- Kumiko Fujiwara
- Department of Oral and Maxillofacial Surgery Graduate School of Medicine and Pharmaceutical Sciences for Research University of Toyama Toyama city Japan
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- Makoto Noguchi
- Department of Oral and Maxillofacial Surgery Graduate School of Medicine and Pharmaceutical Sciences for Research University of Toyama Toyama city Japan
抄録
<jats:title>Abstract</jats:title><jats:sec><jats:title>Objective</jats:title><jats:p>Recent studies have demonstrated the pro‐tumour role of CD36 in multiple cancer types. However, its role has not been well elucidated in oral squamous cell carcinoma (OSCC). Here, we aimed to evaluate the role of CD36 in proliferation and migration of OSCC cells.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Human OSCC cell lines HSC‐2, HSC‐3, HSC‐4 and Ca9‐22 were assessed for proliferation by staining with the cell proliferation marker Ki‐67. We also assessed migration activity, and the expression of cell adhesion molecules such as E‐cadherin and β‐catenin and platelet‐derived growth factor receptors (PDGFRs) of CD36‐positive cells.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>CD36‐positive cells showed increased expression of Ki‐67 and migration activity compared with CD36‐negative cells. Moreover, CD36‐positive cells showed reduced expression of E‐cadherin and β‐catenin, whereas the expression of PDGFRs increased compared with that in CD36‐negative cells.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Our results strongly suggest that CD36 has an important role in facilitating the proliferation and migration activity of OSCC cells, indicating its usefulness in the diagnosis of high‐grade tumour and targeted therapy of oral cancer.</jats:p></jats:sec>
収録刊行物
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- Oral Diseases
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Oral Diseases 26 (4), 745-755, 2020-03-03
Wiley
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詳細情報 詳細情報について
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- CRID
- 1361975845646311168
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- ISSN
- 16010825
- 1354523X
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- データソース種別
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- Crossref
- KAKEN