NRF3-POMP-20S Proteasome Assembly Axis Promotes Cancer Development via Ubiquitin-Independent Proteolysis of p53 and Retinoblastoma Protein
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- Tsuyoshi Waku
- Laboratory for Genetic Code, Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University, Kyoto, Japan
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- Nanami Nakamura
- Laboratory for Genetic Code, Graduate School of Life and Medical Sciences, Doshisha University, Kyoto, Japan
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- Misaki Koji
- Laboratory for Genetic Code, Graduate School of Life and Medical Sciences, Doshisha University, Kyoto, Japan
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- Hidenori Watanabe
- Laboratory for Genetic Code, Graduate School of Life and Medical Sciences, Doshisha University, Kyoto, Japan
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- Hiroki Katoh
- Laboratory for Genetic Code, Graduate School of Life and Medical Sciences, Doshisha University, Kyoto, Japan
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- Chika Tatsumi
- Laboratory for Genetic Code, Graduate School of Life and Medical Sciences, Doshisha University, Kyoto, Japan
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- Natsuko Tamura
- Laboratory for Genetic Code, Graduate School of Life and Medical Sciences, Doshisha University, Kyoto, Japan
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- Atsushi Hatanaka
- Laboratory for Genetic Code, Graduate School of Life and Medical Sciences, Doshisha University, Kyoto, Japan
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- Shuuhei Hirose
- Laboratory for Genetic Code, Graduate School of Life and Medical Sciences, Doshisha University, Kyoto, Japan
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- Hiroyuki Katayama
- Laboratory for Genetic Code, Graduate School of Life and Medical Sciences, Doshisha University, Kyoto, Japan
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- Misato Tani
- Laboratory for Genetic Code, Graduate School of Life and Medical Sciences, Doshisha University, Kyoto, Japan
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- Yuki Kubo
- Laboratory for Genetic Code, Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University, Kyoto, Japan
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- Jun Hamazaki
- Laboratory of Protein Metabolism, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan
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- Takao Hamakubo
- Department of Protein-Protein Interaction Research, Institute for Advanced Medical Sciences, Nippon Medical School, Kanagawa, Japan
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- Akira Watanabe
- Department of Life Science Frontiers, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan
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- Shigeo Murata
- Laboratory of Protein Metabolism, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan
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- Akira Kobayashi
- Laboratory for Genetic Code, Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University, Kyoto, Japan
説明
Proteasomes are essential protease complexes that maintain cellular homeostasis, and aberrant proteasomal activity supports cancer development. The regulatory mechanisms and biological function of the ubiquitin-26S proteasome have been studied extensively, while those of the ubiquitin-independent 20S proteasome system remain obscure. Here, we show that the cap 'n' collar (CNC) family transcription factor NRF3 specifically enhances 20S proteasome assembly in cancer cells and that 20S proteasomes contribute to colorectal cancer development through ubiquitin-independent proteolysis of the tumor suppressor p53 and retinoblastoma (Rb) proteins. The
収録刊行物
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- Molecular and Cellular Biology
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Molecular and Cellular Biology 40 (10), e00597-19-, 2020-04-28
Informa UK Limited
