Discovery of a New Capsular Serotype (6C) within Serogroup 6 of<i>Streptococcus pneumoniae</i>

DOI Web Site 被引用文献6件
  • In Ho Park
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama
  • David G. Pritchard
    Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, Alabama
  • Rob Cartee
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama
  • Angela Brandao
    IOC/FIOCRUZ, Rio de Janeiro, Brazil
  • Maria Cristina C. Brandileone
    Pyogenic and Toxigenic Bacteria Laboratory, Bacteriology Department, Adolfo Lutz Institute, São Paulo, Brazil
  • Moon H. Nahm
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama

書誌事項

公開日
2007-04
権利情報
  • https://journals.asm.org/non-commercial-tdm-license
DOI
  • 10.1128/jcm.02199-06
公開者
American Society for Microbiology

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説明

<jats:title>ABSTRACT</jats:title><jats:p>Using two monoclonal antibodies, we found subtypes among pneumococcal isolates that are typed as serotype 6A by the quellung reaction. The prevalent subtype bound to both monoclonal antibodies and was labeled here 6Aα, whereas the minor subtype bound to only one monoclonal antibody and was labeled 6Aβ. To determine the biochemical nature of the two serologically defined subtypes, we purified capsular polysaccharides (PSs) from the two subtypes and examined their chemical structures with gas-liquid chromatography and mass spectrometry. The study results for 6Aα PS are consistent with the previously published structure of 6A PS, which is →2) galactose (1→3) glucose (1→3) rhamnose (1→3) ribitol (5→phosphate. In contrast, the 6Aβ PS study results show that its repeating unit is →2) glucose 1 (1→3) glucose 2 (1→3) rhamnose (1→3) ribitol (5→phosphate. We propose to continue referring to 6Aα as serotype 6A but to refer to 6Aβ as serotype 6C. Serotype 6C would thus represent the 91st pneumococcal serotype, with 90 pneumococcal serotypes having previously been recognized. This study also demonstrates that a new serotype may exist within an established and well-characterized serogroup or serotype.</jats:p>

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