Role of Bid‐induced mitochondrial outer membrane permeabilization in granzyme B‐induced apoptosis
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- Nigel J Waterhouse
- Cancer Cell Death Laboratory, Cancer Immunology Program, Peter MacCallum Cancer Centre Melbourne Victoria Australia
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- Karin A Sedelies
- Cancer Cell Death Laboratory, Cancer Immunology Program, Peter MacCallum Cancer Centre Melbourne Victoria Australia
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- Joseph A Trapani
- Cancer Cell Death Laboratory, Cancer Immunology Program, Peter MacCallum Cancer Centre Melbourne Victoria Australia
書誌事項
- 公開日
- 2006-02
- 権利情報
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- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
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- 10.1111/j.1440-1711.2005.01416.x
- 公開者
- Wiley
この論文をさがす
説明
<jats:p>Cytotoxic lymphocytes (CL) induce death of their targets by granule exocytosis. During this process, enzymes contained within cytotoxic granules (granzymes) are delivered to the target cell where the enzymes trigger the cell death by cleaving specific substrates. Granzyme B is the only granzyme that has been shown to induce cell death by apoptosis, but the exact pathway by which this is achieved has been the subject of hot debate. Furthermore, several other death‐inducing granzymes have been identified; therefore, the exact contribution of granzyme B to CL‐induced death is unclear. In this study, we discuss our recent findings on granzyme B‐induced cell death and discuss the potential relevance of this pathway to CL‐induced death of viral‐infected and transformed cells.</jats:p>
収録刊行物
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- Immunology & Cell Biology
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Immunology & Cell Biology 84 (1), 72-78, 2006-02
Wiley