Independent Association Between Obstructive Sleep Apnea Severity and Glycated Hemoglobin in Adults Without Diabetes
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- Pascaline Priou
- LUNAM University, Angers, France
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- Marc Le Vaillant
- CERMES, CNRS UMR8211, INSERM U988, EHESS, Villejuif, France
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- Nicole Meslier
- LUNAM University, Angers, France
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- Sylvaine Chollet
- Department of Respiratory Diseases, Nantes University Hospital, Nantes, France
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- Philippe Masson
- Department of Respiratory Diseases, Cholet Hospital, Cholet, France
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- Marie P. Humeau
- Department of Respiratory Diseases, Nouvelles Cliniques Nantaises, Nantes, France
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- Thierry Pigeanne
- Department of Respiratory Diseases, Pôle Santé des Olonnes, Olonnes sur Mer, France
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- Acya Bizieux-Thaminy
- Department of Respiratory Diseases, La Roche sur Yon Hospital, La Roche sur Yon, France
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- François Goupil
- Department of Respiratory Diseases, Le Mans Hospital, Le Mans, France
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- Frédéric Gagnadoux
- LUNAM University, Angers, France
説明
<jats:sec> <jats:title>OBJECTIVE</jats:title> <jats:p>We tested the hypothesis of an independent cross-sectional association between obstructive sleep apnea (OSA) severity and glycated hemoglobin (HbA1c) in adults without known diabetes.</jats:p> </jats:sec> <jats:sec> <jats:title>RESEARCH DESIGN AND METHODS</jats:title> <jats:p>HbA1c was measured in whole-blood samples from 2,139 patients undergoing nocturnal recording for suspected OSA. Participants with self-reported diabetes, use of diabetes medication, or HbA1c value ≥6.5% were excluded from this study. Our final sample size comprised 1,599 patients.</jats:p> </jats:sec> <jats:sec> <jats:title>RESULTS</jats:title> <jats:p>A dose-response relationship was observed between apnea-hypopnea index (AHI) and the percentage of patients with HbA1c >6.0%, ranging from 10.8% for AHI <5 to 34.2% for AHI ≥50. After adjustment for age, sex, smoking habits, BMI, waist circumference, cardiovascular morbidity, daytime sleepiness, depression, insomnia, sleep duration, and study site, odds ratios (95% CIs) for HbA1c >6.0% were 1 (reference), 1.40 (0.84–2.32), 1.80 (1.19–2.72), 2.02 (1.31–3.14), and 2.96 (1.58–5.54) for AHI values <5, 5 to <15, 15 to <30, 30 to <50, and ≥50, respectively. Increasing hypoxemia during sleep was also independently associated with the odds of HbA1c >6.0%.</jats:p> </jats:sec> <jats:sec> <jats:title>CONCLUSIONS</jats:title> <jats:p>Among adults without known diabetes, increasing OSA severity is independently associated with impaired glucose metabolism, as assessed by higher HbA1c values, which may expose them to higher risks of diabetes and cardiovascular disease.</jats:p> </jats:sec>
収録刊行物
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- Diabetes Care
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Diabetes Care 35 (9), 1902-1906, 2012-08-14
American Diabetes Association