Oxidative Stress, Molecular Inflammation and Sarcopenia

DOI Web Site 被引用文献20件
  • Si-Jin Meng
    Institution of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China
  • Long-Jiang Yu
    Institution of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China

説明

<jats:p>Sarcopenia is the decline of muscle mass and strength with age. Evidence suggests that oxidative stress and molecular inflammation play important roles in age-related muscle atrophy. The two factors may interfere with the balance between protein synthesis and breakdown, cause mitochondrial dysfunction, and induce apoptosis. The purpose of this review is to discuss some of the major signaling pathways that are activated or inactivated during the oxidative stress and molecular inflammation seen in aged skeletal muscle. Combined interventions that may be required to reverse sarcopenia, such as exercise, caloric restriction, and nutrition, will also be discussed.</jats:p>

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