Clonal hematopoiesis, with and without candidate driver mutations, is common in the elderly
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- Florian Zink
- deCODE genetics/AMGEN, Reykjavik, Iceland;
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- Simon N. Stacey
- deCODE genetics/AMGEN, Reykjavik, Iceland;
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- Gudmundur L. Norddahl
- deCODE genetics/AMGEN, Reykjavik, Iceland;
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- Michael L. Frigge
- deCODE genetics/AMGEN, Reykjavik, Iceland;
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- Olafur T. Magnusson
- deCODE genetics/AMGEN, Reykjavik, Iceland;
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- Ingileif Jonsdottir
- deCODE genetics/AMGEN, Reykjavik, Iceland;
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- Thorgeir E. Thorgeirsson
- deCODE genetics/AMGEN, Reykjavik, Iceland;
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- Asgeir Sigurdsson
- deCODE genetics/AMGEN, Reykjavik, Iceland;
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- Sigurjon A. Gudjonsson
- deCODE genetics/AMGEN, Reykjavik, Iceland;
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- Julius Gudmundsson
- deCODE genetics/AMGEN, Reykjavik, Iceland;
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- Jon G. Jonasson
- Landspitali-University Hospital, Reykjavik, Iceland;
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- Laufey Tryggvadottir
- Icelandic Cancer Registry, Reykjavik, Iceland; and
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- Thorvaldur Jonsson
- Landspitali-University Hospital, Reykjavik, Iceland;
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- Agnar Helgason
- deCODE genetics/AMGEN, Reykjavik, Iceland;
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- Arnaldur Gylfason
- deCODE genetics/AMGEN, Reykjavik, Iceland;
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- Patrick Sulem
- deCODE genetics/AMGEN, Reykjavik, Iceland;
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- Thorunn Rafnar
- deCODE genetics/AMGEN, Reykjavik, Iceland;
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- Unnur Thorsteinsdottir
- deCODE genetics/AMGEN, Reykjavik, Iceland;
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- Daniel F. Gudbjartsson
- deCODE genetics/AMGEN, Reykjavik, Iceland;
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- Gisli Masson
- deCODE genetics/AMGEN, Reykjavik, Iceland;
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- Augustine Kong
- deCODE genetics/AMGEN, Reykjavik, Iceland;
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- Kari Stefansson
- deCODE genetics/AMGEN, Reykjavik, Iceland;
説明
<jats:title>Key Points</jats:title> <jats:p>Whole-genome sequencing of 11 262 Icelanders reveals that clonal hematopoiesis is very common in the elderly. Somatic mutation of some genes is strongly associated with clonal hematopoiesis, but in most cases, no driver mutations were evident.</jats:p>
収録刊行物
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- Blood
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Blood 130 (6), 742-752, 2017-08-10
American Society of Hematology