Genetic variation in the <i>PNPLA3</i> gene and hepatocellular carcinoma in USA: Risk and prognosis prediction
-
- Manal M. Hassan
- Division of Cancer Medicine, Department of Gastrointestinal Medical Oncology The University of Texas M.D. Anderson Cancer Center Houston Texas
-
- Ahmed Kaseb
- Division of Cancer Medicine, Department of Gastrointestinal Medical Oncology The University of Texas M.D. Anderson Cancer Center Houston Texas
-
- Carol J. Etzel
- Division of Cancer Prevention and Population Science, Department of Epidemiology The University of Texas M.D. Anderson Cancer Center Houston Texas
-
- Hashem El‐Serag
- Department of Gastroenterology and Hepatology Baylor College of Medicine Houston Texas
-
- Margaret R. Spitz
- Department of Molecular and Cellular Biology Baylor College of Medicine Houston Texas
-
- Ping Chang
- Division of Cancer Medicine, Department of Gastrointestinal Medical Oncology The University of Texas M.D. Anderson Cancer Center Houston Texas
-
- Katherine S. Hale
- Department of Systems Biology The University of Texas M.D. Anderson Cancer Center Houston Texas
-
- Mei Liu
- Division of Cancer Prevention and Population Science, Department of Epidemiology The University of Texas M.D. Anderson Cancer Center Houston Texas
-
- Asif Rashid
- Division of Pathology/Lab Medicine, Department of Pathology The University of Texas M.D. Anderson Cancer Center Houston Texas
-
- Mohamed Shama
- Division of Cancer Medicine, Department of Gastrointestinal Medical Oncology The University of Texas M.D. Anderson Cancer Center Houston Texas
-
- James L. Abbruzzese
- Division of Cancer Medicine, Department of Gastrointestinal Medical Oncology The University of Texas M.D. Anderson Cancer Center Houston Texas
-
- Evelyne M. Loyer
- Division of Diagnostic Imaging, Department of Diagnostic Radiology The University of Texas M.D. Anderson Cancer Center Houston Texas
-
- Harmeet Kaur
- Division of Diagnostic Imaging, Department of Diagnostic Radiology The University of Texas M.D. Anderson Cancer Center Houston Texas
-
- Hesham M. Hassabo
- Division of Cancer Medicine, Department of Gastrointestinal Medical Oncology The University of Texas M.D. Anderson Cancer Center Houston Texas
-
- Jean‐Nicolas Vauthey
- Division of Surgery, Department of Surgical Oncology The University of Texas M.D. Anderson Cancer Center Houston Texas
-
- Curtis J. Wray
- Department Surgery/Lyndon B. Johnson The University of Texas Health Science Center at Houston Medical School Houston Texas
-
- Basmah S. Hassan
- Division of Cancer Medicine, Department of Gastrointestinal Medical Oncology The University of Texas M.D. Anderson Cancer Center Houston Texas
-
- Yehuda Z. Patt
- Department of GI Oncology University of New Mexico Cancer Center Albuquerque New Mexico
-
- Ernest Hawk
- Division of Cancer Prevention and Population Science, Department of Epidemiology The University of Texas M.D. Anderson Cancer Center Houston Texas
-
- Khalid M. Soliman
- Division of Cancer Medicine, Department of Gastrointestinal Medical Oncology The University of Texas M.D. Anderson Cancer Center Houston Texas
-
- Donghui Li
- Division of Cancer Medicine, Department of Gastrointestinal Medical Oncology The University of Texas M.D. Anderson Cancer Center Houston Texas
Description
<jats:title>Abstract</jats:title><jats:sec><jats:label /><jats:p>Nonalcoholic fatty liver disease (NAFLD) is an emerging epidemic with high prevalence in Western countries. Genome‐wide association studies had reported that a variation in the patatin‐like phospholipase domain containing 3 (<jats:italic>PNPLA3</jats:italic>) gene is associated with high susceptibility to NAFLD. However, the relationship between this variation and hepatocellular carcinoma (HCC) has not been well established. We investigated the impact of <jats:italic>PNPLA3</jats:italic> genetic variation (rs738409: C>G) on HCC risk and prognosis in the United States by conducting a case−control study that included 257 newly diagnosed and pathologically confirmed Caucasian patients with HCC (cases) and 494 healthy controls. Multivariate logistics and Cox regression models were used to control for the confounding effects of HCC risk and prognostic factors. We observed higher risk of HCC for subjects with a homozygous GG genotype than for those with CC or CG genotypes, the adjusted odds ratio (OR) was 3.21 (95% confidence interval [CI], 1.68–6.41). We observed risk modification among individuals with diabetes mellitus (OR = 19.11; 95% CI, 5.13–71.20). The <jats:italic>PNPLA3</jats:italic> GG genotype was significantly associated with underlying cirrhosis in HCC patients (OR = 2.48; 95% CI, 1.05–5.87). Moreover, GG allele represents an independent risk factor for death. The adjusted hazard ratio of the GG genotype was 2.11 (95% CI, 1.26–3.52) compared with CC and CG genotypes. <jats:italic>PNPLA3</jats:italic> genetic variation (rs738409: C>G) may determine individual susceptibility to HCC development and poor prognosis. Further experimental investigations are necessary for thorough assessment of the hepatocarcinogenic role of <jats:italic>PNPLA3</jats:italic>. © 2013 Wiley Periodicals, Inc.</jats:p></jats:sec>
Journal
-
- Molecular Carcinogenesis
-
Molecular Carcinogenesis 52 (S1), 139-147, 2013-06-15
Wiley
- Tweet
Details 詳細情報について
-
- CRID
- 1361981468540314240
-
- DOI
- 10.1002/mc.22057
-
- ISSN
- 10982744
- 08991987
-
- Data Source
-
- Crossref