Heterogeneous Microtesla SABRE Enhancement of <sup>15</sup>N NMR Signals
-
- Kirill V. Kovtunov
- Laboratory of Magnetic Resonance Microimaging International Tomography Center, SB RAS 3A Institutskaya St. Novosibirsk 630090 Russia
-
- Larisa M. Kovtunova
- Novosibirsk State University 2 Pirogova St. Novosibirsk 630090 Russia
-
- Max E. Gemeinhardt
- Department of Chemistry and Biochemistry Southern Illinois University Carbondale IL 62901 USA
-
- Andrey V. Bukhtiyarov
- Boreskov Institute of Catalysis SB RAS 5 Acad. Lavrentiev Pr. Novosibirsk 630090 Russia
-
- Jonathan Gesiorski
- Department of Chemistry and Biochemistry Southern Illinois University Carbondale IL 62901 USA
-
- Valerii I. Bukhtiyarov
- Boreskov Institute of Catalysis SB RAS 5 Acad. Lavrentiev Pr. Novosibirsk 630090 Russia
-
- Eduard Y. Chekmenev
- Vanderbilt University Institute of Imaging Science (VUIIS) Department of Radiology Department of Biomedical Engineering Department of Physics and Astronomy, Vanderbilt-Ingram Cancer Center (VICC) Nashville TN 37232-2310 USA
-
- Igor V. Koptyug
- Laboratory of Magnetic Resonance Microimaging International Tomography Center, SB RAS 3A Institutskaya St. Novosibirsk 630090 Russia
-
- Boyd M. Goodson
- Department of Chemistry and Biochemistry Southern Illinois University Carbondale IL 62901 USA
抄録
<jats:title>Abstract</jats:title><jats:p>The hyperpolarization of heteronuclei via signal amplification by reversible exchange (SABRE) was investigated under conditions of heterogeneous catalysis and microtesla magnetic fields. Immobilization of [IrCl(COD)(IMes)], [IMes=1,3‐bis(2,4,6‐trimethylphenyl), imidazole‐2‐ylidene; COD=cyclooctadiene] catalyst onto silica particles modified with amine linkers engenders an effective heterogeneous SABRE (HET‐SABRE) catalyst that was used to demonstrate a circa 100‐fold enhancement of <jats:sup>15</jats:sup>N NMR signals in <jats:sup>15</jats:sup>N‐pyridine at 9.4 T following parahydrogen bubbling within a magnetic shield. No <jats:sup>15</jats:sup>N NMR enhancement was observed from the supernatant liquid following catalyst separation, which along with XPS characterization supports the fact that the effects result from SABRE under heterogeneous catalytic conditions. The technique can be developed further for producing catalyst‐free agents via SABRE with hyperpolarized heteronuclear spins, and thus is promising for biomedical NMR and MRI applications.</jats:p>
収録刊行物
-
- Angewandte Chemie International Edition
-
Angewandte Chemie International Edition 56 (35), 10433-10437, 2017-07-28
Wiley
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1361981468552214272
-
- ISSN
- 15213773
- 14337851
-
- データソース種別
-
- Crossref