Heterogeneous Microtesla SABRE Enhancement of <sup>15</sup>N NMR Signals

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  • Kirill V. Kovtunov
    Laboratory of Magnetic Resonance Microimaging International Tomography Center, SB RAS 3A Institutskaya St. Novosibirsk 630090 Russia
  • Larisa M. Kovtunova
    Novosibirsk State University 2 Pirogova St. Novosibirsk 630090 Russia
  • Max E. Gemeinhardt
    Department of Chemistry and Biochemistry Southern Illinois University Carbondale IL 62901 USA
  • Andrey V. Bukhtiyarov
    Boreskov Institute of Catalysis SB RAS 5 Acad. Lavrentiev Pr. Novosibirsk 630090 Russia
  • Jonathan Gesiorski
    Department of Chemistry and Biochemistry Southern Illinois University Carbondale IL 62901 USA
  • Valerii I. Bukhtiyarov
    Boreskov Institute of Catalysis SB RAS 5 Acad. Lavrentiev Pr. Novosibirsk 630090 Russia
  • Eduard Y. Chekmenev
    Vanderbilt University Institute of Imaging Science (VUIIS) Department of Radiology Department of Biomedical Engineering Department of Physics and Astronomy, Vanderbilt-Ingram Cancer Center (VICC) Nashville TN 37232-2310 USA
  • Igor V. Koptyug
    Laboratory of Magnetic Resonance Microimaging International Tomography Center, SB RAS 3A Institutskaya St. Novosibirsk 630090 Russia
  • Boyd M. Goodson
    Department of Chemistry and Biochemistry Southern Illinois University Carbondale IL 62901 USA

抄録

<jats:title>Abstract</jats:title><jats:p>The hyperpolarization of heteronuclei via signal amplification by reversible exchange (SABRE) was investigated under conditions of heterogeneous catalysis and microtesla magnetic fields. Immobilization of [IrCl(COD)(IMes)], [IMes=1,3‐bis(2,4,6‐trimethylphenyl), imidazole‐2‐ylidene; COD=cyclooctadiene] catalyst onto silica particles modified with amine linkers engenders an effective heterogeneous SABRE (HET‐SABRE) catalyst that was used to demonstrate a circa 100‐fold enhancement of <jats:sup>15</jats:sup>N NMR signals in <jats:sup>15</jats:sup>N‐pyridine at 9.4 T following parahydrogen bubbling within a magnetic shield. No <jats:sup>15</jats:sup>N NMR enhancement was observed from the supernatant liquid following catalyst separation, which along with XPS characterization supports the fact that the effects result from SABRE under heterogeneous catalytic conditions. The technique can be developed further for producing catalyst‐free agents via SABRE with hyperpolarized heteronuclear spins, and thus is promising for biomedical NMR and MRI applications.</jats:p>

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