Current Applications of Human Pluripotent Stem Cells: Possibilities and Challenges

DOI Web Site Web Site 被引用文献1件
  • Pai-Jiun Ho
    Regenerative Medicine Research Group, Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan, Taiwan
  • Men-Luh Yen
    Departmant of Primary Medicine and Department of Obstetrics/Gynecology, College of Medicine, National Taiwan University, Taipei, Taiwan
  • Shaw-Fang Yet
    Cardiovascular Research Group, Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan, Taiwan
  • B. Linju Yen
    Regenerative Medicine Research Group, Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan, Taiwan

書誌事項

公開日
2012-05
権利情報
  • http://journals.sagepub.com/page/policies/text-and-data-mining-license
DOI
  • 10.3727/096368911x627507
公開者
SAGE Publications

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説明

<jats:p>Stem cells are self-renewable cells with the differentiation capacity to develop into somatic cells with biological functions. This ability to sustain a renewable source of multi- and/or pluripotential differentiation has brought new hope to the field of regenerative medicine in terms of cell therapy and tissue engineering. Moreover, stem cells are invaluable tools as in vitro models for studying diverse fields, from basic scientific questions such as developmental processes and lineage commitment, to practical application including drug screening and testing. The stem cells with widest differentiation potential are pluripotent stem cells (PSCs), which are rare cells with the ability to generate somatic cells from all three germ layers. PSCs are considered the most optimal choice for therapeutic potential of stem cells, bringing new impetus to the field of regenerative medicine. In this article, we discuss the therapeutic potential of human PSCs (hPSCs) including human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs), reviewing the current preclinical and clinical data using these stem cells. We describe the classification of different sources of hPSCs, ongoing research, and currently encountered clinical obstacles of these novel and versatile human stem cells.</jats:p>

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