Nuclear localization of folate receptor alpha: a new role as a transcription factor
書誌事項
- 公開日
- 2012-12-14
- 権利情報
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- https://creativecommons.org/licenses/by-nc-nd/3.0/
- https://creativecommons.org/licenses/by-nc-nd/3.0/
- DOI
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- 10.1038/srep00980
- 公開者
- Springer Science and Business Media LLC
説明
Folic acid (FA) has traditionally been associated with prevention of neural tube defects; more recent work suggests that it may also be involved in in the prevention of adult onset diseases. As the role of FA in human health and disease expands, it also becomes more critical to understand the mechanisms behind FA action. In this work we examined the hypothesis that folate receptor alpha (FRα) acts as a transcription factor. FRα is a GPI-anchored protein and a component of the caveolae fraction. The work described here shows that FRα translocates to the nucleus, where it binds to cis-regulatory elements at promoter regions of Fgfr4 and Hes1, and regulates their expression. The FRα recognition domain mapped to AT rich regions on the promoters. Until this time FRα has only been considered as a folate transporter, these studies describe a novel role for FRα as a transcription factor.
収録刊行物
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- Scientific Reports
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Scientific Reports 2 (1), 980-, 2012-12-14
Springer Science and Business Media LLC