Acute Diarrhea in West African Children: Diverse Enteric Viruses and a Novel Parvovirus Genus

DOI Web Site 4 Citations
  • Tung G. Phan
    Blood Systems Research Institute, San Francisco, California, USA
  • Nguyen P. Vo
    Blood Systems Research Institute, San Francisco, California, USA
  • Isidore J. O. Bonkoungou
    Laboratoire National de Santé Publique, Ouagadougou, Burkina Faso
  • Amit Kapoor
    Blood Systems Research Institute, San Francisco, California, USA
  • Nicolas Barro
    Laboratoire de Biologie Moléculaire, d'Epidémiologie et Surveillance des Bactéries et Virus Transmis par les Aliments, CRSBAN/UFR-SVT, Université de Ouagadougou, Ouagadougou, Burkina Faso
  • Miguel O'Ryan
    Microbiology and Mycology Program, Faculty of Medicine, University of Chile, Santiago, Chile
  • Beatrix Kapusinszky
    Blood Systems Research Institute, San Francisco, California, USA
  • Chunling Wang
    Division of Infectious Diseases, Stanford University Medical Center, Stanford, California, USA
  • Eric Delwart
    Blood Systems Research Institute, San Francisco, California, USA

Description

<jats:title>ABSTRACT</jats:title> <jats:p> Parvoviruses cause a variety of mild to severe symptoms or asymptomatic infections in humans and animals. During a viral metagenomic analysis of feces from children with acute diarrhea in Burkina Faso, we identified in decreasing prevalence nucleic acids from anelloviruses, dependoviruses, sapoviruses, enteroviruses, bocaviruses, noroviruses, adenoviruses, parechoviruses, rotaviruses, cosavirus, astroviruses, and hepatitis B virus. Sequences from a highly divergent parvovirus, provisionally called bufavirus, were also detected whose NS1 and VP1 proteins showed <39% and <31% identities to those of previously known parvoviruses. Four percent of the fecal samples were PCR positive for this new parvovirus, including a related bufavirus species showing only 72% identity in VP1. The high degree of genetic divergence of these related genomes from those of other parvoviruses indicates the presence of a proposed new <jats:named-content content-type="genus-species">Parvoviridae</jats:named-content> genus containing at least two species. Studies of the tropism and pathogenicity of these novel parvoviruses will be facilitated by the availability of their genome sequences. </jats:p>

Journal

  • Journal of Virology

    Journal of Virology 86 (20), 11024-11030, 2012-10-15

    American Society for Microbiology

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