Fluorescence Spectroscopy In Vivo

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<jats:title>Abstract</jats:title><jats:p>Diagnostic techniques based on optical spectroscopy have the potential to link the biochemical and morphological properties of tissues to individual patient care. In particular, these techniques are fast, noninvasive and quantitative. Furthermore, they can be used to elucidate key tissue features, such as the cellular metabolic rate, vascularity, intravascular oxygenation and alterations in tissue morphology. These tissue features can be interpreted to shed light on a variety of clinical problems, such as precancerous and cancerous growth and atherosclerosis. The goal of this report is to review the development and application of optical spectroscopy in the ultraviolet (UV) and visible (VIS) spectral regions, as a diagnostic tool in clinical applications. A particular emphasis is placed on steady‐state, UV/VIS fluorescence spectroscopy for the detection of precancers and cancers, in vivo.</jats:p>

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