Cytomegalovirus-mediated activation of pyrimidine biosynthesis drives UDP–sugar synthesis to support viral protein glycosylation
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- Stefanie Renee DeVito
- Departments of aBiochemistry and Biophysics and
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- Emilio Ortiz-Riaño
- Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642
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- Luis Martínez-Sobrido
- Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642
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- Joshua Munger
- Departments of aBiochemistry and Biophysics and
書誌事項
- 公開日
- 2014-12-03
- 権利情報
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- http://www.pnas.org/site/misc/userlicense.xhtml
- DOI
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- 10.1073/pnas.1415864111
- 公開者
- Proceedings of the National Academy of Sciences
この論文をさがす
説明
<jats:title>Significance</jats:title> <jats:p>Viruses use the host cell to provide the energy and molecular subunits to assemble viral progeny. The progeny of a variety of viral families possess envelope glycoproteins that are essential for viral infection. The production of these functional glycoproteins requires an ample supply of UDP–sugar subunits that serve as the substrates for glycosylation reactions. Our results indicate that human cytomegalovirus induces a viral metabolic program that activates pyrimidine biosynthesis to drive UDP–sugar biosynthesis. This metabolic activation is important for viral protein glycosylation and high-titer viral replication. Further, our results suggest that this metabolic link between pyrimidine and UDP–sugar biosynthesis is shared between evolutionarily diverse viral families, which may provide novel avenues for antiviral therapeutic intervention.</jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 111 (50), 18019-18024, 2014-12-03
Proceedings of the National Academy of Sciences
