Repeat Left Atrial Catheter Ablation

  • James L. Harrison
    From the Division of Imaging Sciences & Biomedical Engineering, King’s College London (J.L.H., C.S., N.W.L., R.K., S.E.W., K.S.R., J.G., C.A.R., M.W., T.S., R.S.R., M.D.O.), Department of Cardiology (J.L.H., N.W.L., S.E.W., J.G., M.C., C.A.R., M.W, M.D.O.), Guy’s and St. Thomas’ NHS Foundation Trust, London, United Kingdom.
  • Christian Sohns
    From the Division of Imaging Sciences & Biomedical Engineering, King’s College London (J.L.H., C.S., N.W.L., R.K., S.E.W., K.S.R., J.G., C.A.R., M.W., T.S., R.S.R., M.D.O.), Department of Cardiology (J.L.H., N.W.L., S.E.W., J.G., M.C., C.A.R., M.W, M.D.O.), Guy’s and St. Thomas’ NHS Foundation Trust, London, United Kingdom.
  • Nick W. Linton
    From the Division of Imaging Sciences & Biomedical Engineering, King’s College London (J.L.H., C.S., N.W.L., R.K., S.E.W., K.S.R., J.G., C.A.R., M.W., T.S., R.S.R., M.D.O.), Department of Cardiology (J.L.H., N.W.L., S.E.W., J.G., M.C., C.A.R., M.W, M.D.O.), Guy’s and St. Thomas’ NHS Foundation Trust, London, United Kingdom.
  • Rashed Karim
    From the Division of Imaging Sciences & Biomedical Engineering, King’s College London (J.L.H., C.S., N.W.L., R.K., S.E.W., K.S.R., J.G., C.A.R., M.W., T.S., R.S.R., M.D.O.), Department of Cardiology (J.L.H., N.W.L., S.E.W., J.G., M.C., C.A.R., M.W, M.D.O.), Guy’s and St. Thomas’ NHS Foundation Trust, London, United Kingdom.
  • Steven E. Williams
    From the Division of Imaging Sciences & Biomedical Engineering, King’s College London (J.L.H., C.S., N.W.L., R.K., S.E.W., K.S.R., J.G., C.A.R., M.W., T.S., R.S.R., M.D.O.), Department of Cardiology (J.L.H., N.W.L., S.E.W., J.G., M.C., C.A.R., M.W, M.D.O.), Guy’s and St. Thomas’ NHS Foundation Trust, London, United Kingdom.
  • Kawal S. Rhode
    From the Division of Imaging Sciences & Biomedical Engineering, King’s College London (J.L.H., C.S., N.W.L., R.K., S.E.W., K.S.R., J.G., C.A.R., M.W., T.S., R.S.R., M.D.O.), Department of Cardiology (J.L.H., N.W.L., S.E.W., J.G., M.C., C.A.R., M.W, M.D.O.), Guy’s and St. Thomas’ NHS Foundation Trust, London, United Kingdom.
  • Jaswinder Gill
    From the Division of Imaging Sciences & Biomedical Engineering, King’s College London (J.L.H., C.S., N.W.L., R.K., S.E.W., K.S.R., J.G., C.A.R., M.W., T.S., R.S.R., M.D.O.), Department of Cardiology (J.L.H., N.W.L., S.E.W., J.G., M.C., C.A.R., M.W, M.D.O.), Guy’s and St. Thomas’ NHS Foundation Trust, London, United Kingdom.
  • Michael Cooklin
    From the Division of Imaging Sciences & Biomedical Engineering, King’s College London (J.L.H., C.S., N.W.L., R.K., S.E.W., K.S.R., J.G., C.A.R., M.W., T.S., R.S.R., M.D.O.), Department of Cardiology (J.L.H., N.W.L., S.E.W., J.G., M.C., C.A.R., M.W, M.D.O.), Guy’s and St. Thomas’ NHS Foundation Trust, London, United Kingdom.
  • C. Aldo Rinaldi
    From the Division of Imaging Sciences & Biomedical Engineering, King’s College London (J.L.H., C.S., N.W.L., R.K., S.E.W., K.S.R., J.G., C.A.R., M.W., T.S., R.S.R., M.D.O.), Department of Cardiology (J.L.H., N.W.L., S.E.W., J.G., M.C., C.A.R., M.W, M.D.O.), Guy’s and St. Thomas’ NHS Foundation Trust, London, United Kingdom.
  • Matthew Wright
    From the Division of Imaging Sciences & Biomedical Engineering, King’s College London (J.L.H., C.S., N.W.L., R.K., S.E.W., K.S.R., J.G., C.A.R., M.W., T.S., R.S.R., M.D.O.), Department of Cardiology (J.L.H., N.W.L., S.E.W., J.G., M.C., C.A.R., M.W, M.D.O.), Guy’s and St. Thomas’ NHS Foundation Trust, London, United Kingdom.
  • Tobias Schaeffter
    From the Division of Imaging Sciences & Biomedical Engineering, King’s College London (J.L.H., C.S., N.W.L., R.K., S.E.W., K.S.R., J.G., C.A.R., M.W., T.S., R.S.R., M.D.O.), Department of Cardiology (J.L.H., N.W.L., S.E.W., J.G., M.C., C.A.R., M.W, M.D.O.), Guy’s and St. Thomas’ NHS Foundation Trust, London, United Kingdom.
  • Reza S. Razavi
    From the Division of Imaging Sciences & Biomedical Engineering, King’s College London (J.L.H., C.S., N.W.L., R.K., S.E.W., K.S.R., J.G., C.A.R., M.W., T.S., R.S.R., M.D.O.), Department of Cardiology (J.L.H., N.W.L., S.E.W., J.G., M.C., C.A.R., M.W, M.D.O.), Guy’s and St. Thomas’ NHS Foundation Trust, London, United Kingdom.
  • Mark D. O’Neill
    From the Division of Imaging Sciences & Biomedical Engineering, King’s College London (J.L.H., C.S., N.W.L., R.K., S.E.W., K.S.R., J.G., C.A.R., M.W., T.S., R.S.R., M.D.O.), Department of Cardiology (J.L.H., N.W.L., S.E.W., J.G., M.C., C.A.R., M.W, M.D.O.), Guy’s and St. Thomas’ NHS Foundation Trust, London, United Kingdom.

書誌事項

タイトル別名
  • Cardiac Magnetic Resonance Prediction of Endocardial Voltage and Gaps in Ablation Lesion Sets

抄録

<jats:sec> <jats:title>Background—</jats:title> <jats:p>Studies have reported an inverse relationship between late gadolinium enhancement (LGE) cardiac magnetic resonance (CMR) signal intensity and left atrial (LA) endocardial voltage after LA ablation. However, there is controversy regarding the reproducibility of atrial LGE CMR and its ability to identify gaps in ablation lesions. Using systematic and objective techniques, this study examines the correlation between atrial CMR and endocardial voltage.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods and Results—</jats:title> <jats:p> Twenty patients who had previous ablation for atrial fibrillation and represented with paroxysmal atrial fibrillation or atrial tachycardia underwent preablation LGE CMR. During the ablation procedure, high-density point-by-point Carto voltage maps were acquired. Three-dimensional CMR reconstructions were registered with the Carto anatomies to allow comparison of voltage and LGE signal intensity. Signal intensities around the left and right pulmonary vein antra and along the LA roof and mitral lines on the CMR-segmented LA shells were extracted to examine differences between electrically isolated and reconnected lesions. There were a total of 6767 data points across the 20 patients. Only 119 (1.8%) of the points were ≤0.05 mV. There was only a weak inverse correlation between either unipolar ( <jats:italic>r</jats:italic> =−0.18) or bipolar ( <jats:italic>r</jats:italic> =−0.17) voltage and LGE CMR signal intensities with low voltage occurring across a large range of signal intensities. Signal intensities were not statistically different for electrically isolated and reconnected lesions. </jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions—</jats:title> <jats:p>This study demonstrates that there is only a weak point-by-point relationship between LGE CMR and endocardial voltage in patients undergoing repeat LA ablation. Using an objective method of assessing gaps in ablation lesions, LGE CMR is unable to reliably predict sites of electrical conduction.</jats:p> </jats:sec>

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