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- Miao Teng
- Department of Burn and Plastic Surgery The First Affiliated Hospital of Chongqing Medical University Chongqing China
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- Yuesheng Huang
- Institute of Burn Research State Key Laboratory of Trauma, Burns and Combined Injury Southwest Hospital The Third Military Medical University Chongqing China
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- Hengshu Zhang
- Department of Burn and Plastic Surgery The First Affiliated Hospital of Chongqing Medical University Chongqing China
書誌事項
- 公開日
- 2014-03
- 権利情報
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- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
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- 10.1111/wrr.12152
- 公開者
- Wiley
この論文をさがす
説明
<jats:title>Abstract</jats:title><jats:p>Wound healing is a complex but well‐orchestrated tissue repair process composed of a series of molecular and cellular events conducted by various types of cells and extracellular matrix. Despite a variety of therapeutic strategies proposed to accelerate the healing of acute and/or chronic wounds over the past few decades, effective treatment of chronic nonhealing wounds still remains a challenge. Due to the recent advances in stem cell research, a dramatic enthusiasm has been drawn to the application of stem cells in regenerative medicine. Both embryonic and adult stem cells have prolonged self‐renewal capacity and are able to differentiate into various tissue types. Nevertheless, use of embryonic stem cells is limited, owing to ethical concerns and legal restrictions. Adult stem cells, which could be isolated from bone marrow, umbilical cord blood, adipose tissue, skin and hair follicles,are being explored extensively to facilitate the healing of both acute and chronic wounds. The current article summarizes recent research on various types of stem cell‐based strategies applied to improve wound healing. In addition, future directions of stem cell‐based therapy in wound healing have also been discussed. Finally, despite its apparent advantages, limitations and challenges of stem cell therapy are discussed.</jats:p>
収録刊行物
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- Wound Repair and Regeneration
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Wound Repair and Regeneration 22 (2), 151-160, 2014-03
Wiley
