Pervasive head-to-tail insertions of DNA templates mask desired CRISPR-Cas9–mediated genome editing events
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- Boris V. Skryabin
- Medical Faculty, Core Facility Transgenic Animal and Genetic Engineering Models (TRAM), University of Muenster, Muenster, Germany.
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- Delf-Magnus Kummerfeld
- Medical Faculty, Core Facility Transgenic Animal and Genetic Engineering Models (TRAM), University of Muenster, Muenster, Germany.
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- Leonid Gubar
- Medical Faculty, Core Facility Transgenic Animal and Genetic Engineering Models (TRAM), University of Muenster, Muenster, Germany.
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- Birte Seeger
- Medical Faculty, Core Facility Transgenic Animal and Genetic Engineering Models (TRAM), University of Muenster, Muenster, Germany.
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- Helena Kaiser
- Medical Faculty, Core Facility Transgenic Animal and Genetic Engineering Models (TRAM), University of Muenster, Muenster, Germany.
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- Anja Stegemann
- Medical Faculty, Core Facility Transgenic Animal and Genetic Engineering Models (TRAM), University of Muenster, Muenster, Germany.
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- Johannes Roth
- Institute of Immunology, University Hospital Muenster, Muenster, Germany.
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- Sven G. Meuth
- Clinic of Neurology with Institute of Translational Neurology, University Hospital Muenster, Muenster, Germany.
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- Hermann Pavenstädt
- Internal Medicine D, University Hospital Muenster, Muenster, Germany.
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- Joanna Sherwood
- Institute of Experimental Musculoskeletal Medicine (IMM), University Hospital Muenster, Muenster, Germany.
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- Thomas Pap
- Institute of Experimental Musculoskeletal Medicine (IMM), University Hospital Muenster, Muenster, Germany.
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- Roland Wedlich-Söldner
- Institute of Cell Dynamics and Imaging, University of Muenster, Muenster, Germany.
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- Cord Sunderkötter
- Department of Dermatology and Venereology, University Hospital Halle, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.
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- Yuri B. Schwartz
- Department of Molecular Biology, Umeå University, 901 87 Umeå, Sweden.
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- Juergen Brosius
- Institute of Experimental Pathology (ZMBE), University of Muenster, Muenster, Germany.
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- Timofey S. Rozhdestvensky
- Medical Faculty, Core Facility Transgenic Animal and Genetic Engineering Models (TRAM), University of Muenster, Muenster, Germany.
説明
<jats:p>Knock-in genome targeting risks: Comprehensive locus analysis is essential for precision chromosome-editing identification.</jats:p>
収録刊行物
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- Science Advances
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Science Advances 6 (7), eaax2941-, 2020-02-14
American Association for the Advancement of Science (AAAS)
