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- Kristina D. Desmet
- Department of Clinical Laboratory Sciences, University of Wisconsin–Milwaukee, Milwaukee, Wisconsin.
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- David A. Paz
- Department of Neurology, Medical College of Wisconsin, Milwaukee, Wisconsin.
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- Jesse J. Corry
- Department of Neurology, Medical College of Wisconsin, Milwaukee, Wisconsin.
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- Janis T. Eells
- Department of Clinical Laboratory Sciences, University of Wisconsin–Milwaukee, Milwaukee, Wisconsin.
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- Margaret T.T. Wong-Riley
- Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin.
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- Michele M. Henry
- Department of Ophthalmology, Medical College of Wisconsin, Milwaukee, Wisconsin.
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- Ellen V. Buchmann
- Department of Neurology, Medical College of Wisconsin, Milwaukee, Wisconsin.
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- Mary P. Connelly
- Department of Neurology, Medical College of Wisconsin, Milwaukee, Wisconsin.
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- Julia V. Dovi
- Department of Neurology, Medical College of Wisconsin, Milwaukee, Wisconsin.
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- Huan Ling Liang
- Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin.
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- Diane S. Henshel
- School of Public and Environmental Affairs, Indiana University, Bloomington, Indiana.
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- Ronnie L. Yeager
- School of Public and Environmental Affairs, Indiana University, Bloomington, Indiana.
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- Deborah S. Millsap
- School of Public and Environmental Affairs, Indiana University, Bloomington, Indiana.
-
- Jinhwan Lim
- School of Public and Environmental Affairs, Indiana University, Bloomington, Indiana.
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- Lisa J. Gould
- Department of Plastic Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin.
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- Rina Das
- Department of Molecular Pathology, Walter Reed Army Institute of Research, Silver Spring, Maryland.
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- Marti Jett
- Department of Molecular Pathology, Walter Reed Army Institute of Research, Silver Spring, Maryland.
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- Brian D. Hodgson
- Department of Dentistry, Children's Hospital of Wisconsin, Milwaukee, Wisconsin.
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- David Margolis
- Department of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin.
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- Harry T. Whelan
- Department of Neurology, Medical College of Wisconsin, Milwaukee, Wisconsin.
書誌事項
- 公開日
- 2006-04
- 権利情報
-
- https://journals.sagepub.com/page/policies/text-and-data-mining-license
- DOI
-
- 10.1089/pho.2006.24.121
- 公開者
- SAGE Publications
この論文をさがす
説明
<jats:p> This review presents current research on the use of far-red to near-infrared (NIR) light treatment in various <jats:italic toggle="yes">in vitro</jats:italic> and <jats:italic toggle="yes">in vivo</jats:italic> models. Low-intensity light therapy, commonly referred to as "photobiomodulation," uses light in the far-red to near-infrared region of the spectrum (630–1000 nm) and modulates numerous cellular functions. Positive effects of NIR–light-emitting diode (LED) light treatment include acceleration of wound healing, improved recovery from ischemic injury of the heart, and attenuated degeneration of injured optic nerves by improving mitochondrial energy metabolism and production. Various <jats:italic toggle="yes">in vitro</jats:italic> and <jats:italic toggle="yes">in vivo</jats:italic> models of mitochondrial dysfunction were treated with a variety of wavelengths of NIR-LED light. These studies were performed to determine the effect of NIR-LED light treatment on physiologic and pathologic processes. NIRLED light treatment stimulates the photoacceptor cytochrome <jats:italic toggle="yes">c</jats:italic> oxidase, resulting in increased energy metabolism and production. NIR-LED light treatment accelerates wound healing in ischemic rat and murine diabetic wound healing models, attenuates the retinotoxic effects of methanol-derived formic acid in rat models, and attenuates the developmental toxicity of dioxin in chicken embryos. Furthermore, NIR-LED light treatment prevents the development of oral mucositis in pediatric bone marrow transplant patients. The experimental results demonstrate that NIR-LED light treatment stimulates mitochondrial oxidative metabolism <jats:italic toggle="yes">in vitro</jats:italic> , and accelerates cell and tissue repair <jats:italic toggle="yes">in vivo</jats:italic> . NIR-LED light represents a novel, noninvasive, therapeutic intervention for the treatment of numerous diseases linked to mitochondrial dysfunction. </jats:p>
収録刊行物
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- Photomedicine and Laser Surgery
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Photomedicine and Laser Surgery 24 (2), 121-128, 2006-04
SAGE Publications