Three-Dimensional Structure of Human Serum Albumin

DOI Web Site 被引用文献9件
  • Daniel C. Carter
    National Aeronautics and Space Administration, Space Sciences Laboratory, Biophysics Branch, Marshall Space Flight Center, AL 35812.
  • Xiao-Min He
    National Aeronautics and Space Administration, Space Sciences Laboratory, Biophysics Branch, Marshall Space Flight Center, AL 35812.
  • Sibyl H. Munson
    National Aeronautics and Space Administration, Space Sciences Laboratory, Biophysics Branch, Marshall Space Flight Center, AL 35812.
  • Pamela D. Twigg
    National Aeronautics and Space Administration, Space Sciences Laboratory, Biophysics Branch, Marshall Space Flight Center, AL 35812.
  • Kim M. Gernert
    National Aeronautics and Space Administration, Space Sciences Laboratory, Biophysics Branch, Marshall Space Flight Center, AL 35812.
  • M. Beth Broom
    National Aeronautics and Space Administration, Space Sciences Laboratory, Biophysics Branch, Marshall Space Flight Center, AL 35812.
  • Teresa Y. Miller
    National Aeronautics and Space Administration, Space Sciences Laboratory, Biophysics Branch, Marshall Space Flight Center, AL 35812.

書誌事項

公開日
1989-06-09
DOI
  • 10.1126/science.2727704
公開者
American Association for the Advancement of Science (AAAS)

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説明

<jats:p> The three-dimensional structure of human serum albumin has been solved at 6.0 angstrom (Å) resolution by the method of multiple isomorphous replacement. Crystals were grown from solutions of polyethylene glycol in the infrequently observed space group <jats:italic>P</jats:italic> 42 <jats:sub>1</jats:sub> 2 (unit cell constants <jats:italic>a</jats:italic> = <jats:italic>b</jats:italic> = 186.5 ± 0.5 Å and <jats:italic>c</jats:italic> = 81.0 ± 0.5 Å) and diffracted x-rays to lattice <jats:italic>d</jats:italic> -spacings of less than 2.9 A. The electron density maps are of high quality and revealed the structure as a predominantly α-helical globin protein in which the course of the polypeptide can be traced. The binding loci of several organic compounds have been determined. </jats:p>

収録刊行物

  • Science

    Science 244 (4909), 1195-1198, 1989-06-09

    American Association for the Advancement of Science (AAAS)

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